Evidence map›Paper›PMID 37798081›Full record

Observational studyArchives of disease in childhood2024

Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study.

Stavroula Anastasopoulou, Eva Svensson, Ronny Wickström, Olof Hertting, Malin Ryd Rinder, Rutger Bennet, Margareta Eriksson

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Archives of disease in childhood, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stavroula AnastasopoulouDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden stavroula.anastasopoulou@ki.se.ORCID 0000-0002-4210-0064
Eva SvenssonPediatric Neurology Department, Karolinska University Hospital, Stockholm, Sweden.
Ronny WickströmDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Olof HerttingDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Malin Ryd RinderDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Rutger BennetDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Margareta ErikssonDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs).

designObservational population-based cohort study.

settingNorthern Stockholm. PATIENTS: Patients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022.

main outcome measuresThe prevalence of seizures in hospitalised patients due to SARS-CoV-2, the evaluation of assumed predictors of seizures and the comparison of severity markers in patients with SARS-CoV-2 versus other RTIs.

results32 of 239 included patients (13.4%) admitted due to SARS-CoV-2 infection had seizures. Central nervous system (CNS) disease and the omicron period had significantly increased OR for seizures (OR: 5.12; CI: 2.06 to 12.72 and OR: 3.01; CI: 1.15 to 7.88, respectively). Seizures in patients with SARS-CoV-2 were more common in children older than 5 years (p=0.001), even in the absence of fever (p=0.007), as compared with other viral RTIs. The duration of hospitalisation was longer in patients with seizures due to other viral RTIs (p=0.023). There was no significant difference regarding severity markers of seizures between the two groups.

conclusionsCNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs.

Indexed as

COVID-19Respiratory Tract InfectionsChildChild, PreschoolCohort StudiesHumansPandemicsSARS-CoV-2SeizuresCovid-19EpidemiologyNeurologyPaediatrics

Identifiers

PMID37798081
PMCPMC10850622
OpenAlexW4387363189

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.