Observational studyJournal of thrombosis and haemostasis : JTH2024
Doing more with less: low-titer group O whole blood resulted in less total transfusions and an independent association with survival in adults with severe traumatic hemorrhage.
Observational study in Journal of thrombosis and haemostasis : JTH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2026Review
- Dynamics of platelet activation in cold-stored low-titer group O whole blood over 8 days: insights relative to standard platelet concentrates.Intensive care medicine experimental · 2026Article
- A stochastic, physiology-based digital twin model of hemostasis and oxygenation in trauma resuscitation.Research square · 2026Article
- Whole blood storage time impairs clot strength with minimal change in functional fibrinogen concentration.Transfusion · 2026Article
- Revisiting whole blood transfusion for the massively bleeding patient: The origins of resistance to change.Transfusion · 2026Article
- Collaboration is key for national preparedness: The hospital's role in whole blood rotation models.Transfusion · 2026Article
- The THOR network best practices for females of childbearing potential with life-threatening hemorrhage: Guidance for emergency medical services and hospitals.Transfusion · 2026Review
- Article
- Pathogen-Reduced Low-Titer Group O Whole Blood for Managing Massive Blood Loss in Prehospital and Early Hospital Settings: An In Vitro Study.Journal of clinical medicine · 2025Article
- Article
- Platelet recruitment kinetics are impacted by von Willebrand factor quality in hemostatic adjuncts.Blood vessels, thrombosis & hemostasis · 2025Article
- Incorrect blood typing and mis-transfusion due to low-titer group O whole blood resuscitation.Transfusion · 2025Article
- Article
- Sex-based disparities in low-titer O whole blood utilization and mortality among severely injured trauma patients.Transfusion · 2025Article
- A national database review of whole blood use among females of childbearing potential experiencing traumatic hemorrhage.Transfusion · 2025Article
- Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period.Frontiers in cell and developmental biology · 2025Article
- Microfluidics in Assessing Platelet Function.Journal of visualized experiments : JoVE · 2024Article
- Use of low titer O whole blood in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.Transfusion · 2024Article
- Maternal red blood cell alloimmunization prevalence in the United States.Blood advances · 2024Article
- Transforming research to improve therapies for trauma in the twenty-first century.Critical care (London, England) · 2024Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLow-titer group O whole blood (LTOWB) or component therapy (CT) may be used to resuscitate hemorrhaging trauma patients. LTOWB may have clinical and logistical benefits and may improve survival.
objectivesWe hypothesized LTOWB would improve 24-hour survival in hemorrhaging patients and would be safe and equally efficacious in non-group O compared with group O patients.
methodsAdult trauma patients with massive transfusion protocol activations were enrolled in this observational study. The primary outcome was 24-hour mortality. Secondary outcomes included 72-hour total blood product use. A Cox regression determined the independent associations with 24-hour mortality.
resultsIn total, 348 patients were included (CT, n = 180; LTOWB, n = 168). Demographics were similar between cohorts. Unadjusted 24-hour mortality was reduced in LTOWB vs CT: 8% vs 19% (P = .003), but 6-hour and 28-day mortality were similar. In an adjusted analysis with multivariable Cox regression, LTOWB was independently associated with reduced 24-hour mortality (hazard ratio, 0.21; 95% CI, 0.07-0.67; P = .004). LTOWB patients received significantly less 72-hour total blood products (80.9 [41.6-139.3] mL/kg vs 48.9 [25.9-106.9] mL/kg; P < .001). In stratified 24-hour survival analyses, LTOWB was associated with improved survival for patients in shock or with coagulopathy. LTOWB use in non-group O patients was not associated with increased mortality, organ injury, or adverse events.
conclusionIn this hypothesis-generating study, LTOWB use was independently associated with improved 24-hour survival, predominantly in patients with shock or coagulopathy. LTOWB also resulted in a 40% reduction in blood product use which equates to a median 2.4 L reduction in transfused products.
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