ReviewScience (New York, N.Y.)2023
Deep-time paleogenomics and the limits of DNA survival.
Review in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- Ground squirrel coprolites preserve complex archives of ancient environmental DNA over 700,000 years.Nature communications · 2026Article
- Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Ancient DNA from the Upper Paleolithic mammoth ivory of Hohle Fels, Germany.Scientific reports · 2026Article
- Assessing the Potential of Ancient Protein Sequences in the Study of Hominid Evolution.Genome biology and evolution · 2026Article
- DNA virus-host patterns in lake and marine environments over the last glacial cycle.The ISME journal · 2026Article
- Mitochondrial genomes of Middle Pleistocene horses from the open-air site complex of Schöningen.Nature ecology & evolution · 2025Article
- Genomic and morphological analysis reveals long-term mammoth hybridization in British Columbia, Canada.Biology letters · 2025Article
- Navigating Past Oceans: Comparing Metabarcoding and Metagenomics of Marine Ancient Sediment Environmental DNA.Molecular ecology resources · 2025Article
- A Programmed DNA Dynamic Assembly-Guided Molecular Amplifier for Authentic Information Decryption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A High-Throughput Ancient DNA Extraction Method for Large-Scale Sample Screening.Molecular ecology resources · 2025Article
- A Million Years of Mammoth Mitogenome Evolution.Molecular biology and evolution · 2025Article
- Review
- Museomics and morphological analyses of historical and contemporary peninsular Italian wolf (Canis lupus italicus) samples.Scientific reports · 2025Article
- Ancient DNA data hold insights into past organisms and ecosystems - handle them with more care.Nature · 2024Article
- Cellular, Molecular, and Genetic Mechanisms of Avian Beak Development and Evolution.Annual review of genetics · 2024Review
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.BMC genomics · 2024Review
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.bioRxiv : the preprint server for biology · 2024Article
- Nanoscopic imaging of ancient protein and vasculature offers insight into soft tissue and biomolecule fossilization.iScience · 2024Article
- Unraveling the diversity and cultural heritage of fruit crops through paleogenomics.Trends in genetics : TIG · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Although most ancient DNA studies have focused on the last 50,000 years, paleogenomic approaches can now reach into the early Pleistocene, an epoch of repeated environmental changes that shaped present-day biodiversity. Emerging deep-time genomic transects, including from DNA preserved in sediments, will enable inference of adaptive evolution, discovery of unrecognized species, and exploration of how glaciations, volcanism, and paleomagnetic reversals shaped demography and community composition. In this Review, we explore the state-of-the-art in paleogenomics and discuss key challenges, including technical limitations, evolutionary divergence and associated biases, and the need for more precise dating of remains and sediments. We conclude that with improvements in laboratory and computational methods, the emerging field of deep-time paleogenomics will expand the range of questions addressable using ancient DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.