Evidence map›Paper›PMID 37796764›Full record

ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2024

Influence of

Farhana Islam, Leen Magarbeh, Samar S M Elsheikh, Stefan Kloiber, Caroline W Espinola, Venkat Bhat, Benicio N Frey, Roumen Milev, Claudio N Soares, Sagar V Parikh and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pharmaceuticals (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 3 countries.

Farhana IslamCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0003-4800-0723
Leen MagarbehCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Samar S M ElsheikhCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0002-5368-312X
Stefan KloiberCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0002-6838-4114
Caroline W EspinolaDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Venkat BhatInterventional Psychiatry Program, St. Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-8768-1173
Benicio N FreyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Roumen MilevDepartment of Psychiatry, Queen's University, Providence Care, Kingston, Ontario, Canada.
Claudio N SoaresDepartment of Psychiatry, Queen's University, Providence Care, Kingston, Ontario, Canada.
Sagar V ParikhDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4817-3042
Franca PlacenzaCentre for Mental Health, University Health Network, Toronto, Ontario, Canada.
Stefanie HasselDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Valerie H TaylorDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Francesco LeriDepartment of Psychology and Neuroscience, University of Guelph, Guelph, Ontario, Canada.
Pierre BlierThe Royal Institute of Mental Health Research, Ottawa, Ontario, Canada.
Rudolf UherDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-2998-0546
Faranak FarzanMechatronic Systems Engineering, Simon Fraser University, Surrey, British Columbia, Canada.
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7142-4669
Gustavo TureckiMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada.
Jane A FosterDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Susan RotzingerInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Sidney H KennedyInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5339-7185
Daniel J MüllerCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0003-4978-4400
Centre for Addiction and Mental Health · CASt. Michael's Hospital · CAQueen's University · CAUniversity Health Network · CAUniversity of Calgary · CADalhousie University · CADouglas Mental Health University Institute · CARoyal Ottawa Mental Health Centre · CASimon Fraser University · CASt. Joseph’s Healthcare Hamilton · CAUniversity of British Columbia · CAUniversity of Guelph · CAUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTreatment-emergent sexual dysfunction is frequently reported by individuals with major depressive disorder (MDD) on antidepressants, which negatively impacts treatment adherence and efficacy. We investigated the association of polymorphisms in pharmacokinetic genes encoding cytochrome-P450 drug-metabolizing enzymes,

methodsA total of 178 adults with MDD received treatment with escitalopram (ESC) from weeks 0-8 (Phase I). At week 8, nonresponders were augmented with aripiprazole (ARI) (i.e., ESC + ARI,

resultsIn ESC-Only,

conclusions

Indexed as

Cytochrome P-450 CYP2D6Major Depressive DisorderAdultAripiprazoleATP Binding Cassette Transporter, Subfamily BBiomarkersCanadaCitalopramCytochrome P-450 CYP2C19DepressionEscitalopramFemaleHumansMaleABCB1 protein, humanAripiprazoleATP Binding Cassette Transporter, Subfamily BBiomarkersCitalopramCYP2C19 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6EscitalopramABCB1adverse eventsAntidepressantsaripiprazoleCYP2C19CYP2D6depressionescitaloprampharmacogeneticssexual dysfunction

Identifiers

PMID37796764
PMCPMC10874600
OpenAlexW4387364045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.