Evidence map›Paper›PMID 37796541›Full record

ArticleJournal of psychopathology and clinical science2023

Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.

K Juston Osborne, Wendy Zhang, Tina Gupta, Jaclyn Farrens, McKena Geiger, Brian Kraus, Chloe Krugel, Robin Nusslock, Emily S Kappenman, Vijay A Mittal

Abstract read
In one paragraph

Article in Journal of psychopathology and clinical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

K Juston OsborneDepartment of Psychology, Northwestern University.
Wendy ZhangDepartment of Psychology, San Diego State University.
Tina GuptaDepartment of Psychology, Northwestern University.
Jaclyn FarrensDepartment of Psychology, San Diego State University.
McKena GeigerDepartment of Psychology, San Diego State University.
Brian KrausDepartment of Psychology, Northwestern University.
Chloe KrugelDepartment of Psychology, Northwestern University.
Robin NusslockDepartment of Psychology, Northwestern University.
Emily S KappenmanDepartment of Psychology, San Diego State University.
Vijay A MittalDepartment of Psychology, Northwestern University.

Funding

CLINICAL RESEARCH TRAINING FOR PSYCHOLOGISTST32MH018269 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHELE D LEVINE · 1986 to 2026
$6.3M
Neural Habituation in Ultra High-Risk YouthR21MH110374 · NIMH · NORTHWESTERN UNIVERSITY · PI MITTAL, VIJAY A · 2017 to 2018
$445k
The Neural Mechanisms of Motor Dysfunction in Clinical High-Risk Youth.F31MH123121 · NIMH · NORTHWESTERN UNIVERSITY · PI OSBORNE, KENNETH JUSTON · 2021 to 2022
$59k
NIH HHSNIMH NIH HHS F31 MH123121NIMH NIH HHS R21 MH110374NIMH NIH HHS T32 MH018269
6 · The paper itself

Abstract

Deficits in emotion processing are core features of psychotic disorders. Electrophysiology research in schizophrenia suggests deficits in sustained engagement with emotional content (indexed by the late positive potential [LPP]) may contribute to emotion processing impairments. Despite similar behavioral emotion processing dysfunction in those at clinical high risk (CHR) for psychosis, limited research has examined neural mechanisms of impaired emotion processing in the high-risk period, where research can inform risk models. To examine mechanisms of emotion processing deficits in those at CHR for psychosis, the present study used a passive viewing task to elicit the LPP in response to emotionally engaging and neutral stimuli in 28 CHR and 32 control participants (60% female). Relative to controls, CHR participants showed reduced LPP amplitude when viewing unpleasant images (

Indexed as

Psychotic DisordersSchizophreniaElectroencephalographyEmotionsEvoked PotentialsFemaleHumansMale

Identifiers

PMID37796541
PMCPMC11812458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.