Evidence map›Paper›PMID 37796494›Full record

ArticleAnalytical chemistry2023

Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems.

Allison K Stewart, Matthew H Foley, Michael K Dougherty, Sarah K McGill, Ajay S Gulati, Emily C Gentry, Lee R Hagey, Pieter C Dorrestein, Casey M Theriot, James N Dodds and 1 more

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. MS/MS Mass Spectrometry Filtering Tree for Bile Acid Isomer Annotation.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Allison K StewartDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Matthew H FoleyDepartment of Pathobiology and Population Health, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, United States.
Michael K DoughertyDepartment of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States.
Sarah K McGillDepartment of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States.
Ajay S GulatiDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Emily C GentryDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-0016-8132
Lee R HageyDivision of Gastroenterology, Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093, United States.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, Departments of Pharmacology and Pediatrics, University of California at San Diego, La Jolla, California 92093, United States.
Casey M TheriotDepartment of Pathobiology and Population Health, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, United States.
James N DoddsDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27607, United States.ORCID 0000-0002-9702-2294
Erin S BakerDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27607, United States.ORCID 0000-0001-5246-2213
University of North Carolina at Chapel Hill · USNorth Carolina State University · USUniversity of California San Diego · USUniversity of Montana · USVirginia Tech · US

Funding

Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu · 2017 to 2026
$21.2M
Uncovering the Mechanisms of PFAS-induced ImmunotoxicityP42ES031009 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOPPIN, JANE · 2020 to 2024
$9.3M
GASTROENTEROLOGY RESEARCH TRAININGT32DK007737 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEHZAD Z. SHEIKH · 1996 to 2026
$7.8M
Understanding the role of lipids in structure and function of membrane proteinsRM1GM145416 · NIGMS · TEXAS A&M UNIVERSITY · PI Erin S Baker, Arthur D Laganowsky · 2022 to 2026
$7.4M
DIGESTIVE DISEASES EPIDEMIOLOGY TRAINING PROGRAMT32DK007634 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1990 to 2026
$7.4M
Reverse Metabolomics for the Discovery of Disease Associated Microbial MoleculesR01DK136117 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2023 to 2026
$2.9M
Increasing the Coverage, Sensitivity and Specificity of Rapid Lipidomic MeasurementsR01GM141277 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, ERIN S · 2022 to 2025
$1.2M
NIDDK NIH HHS R01 DK136117NIDDK NIH HHS T32 DK007634NIDDK NIH HHS T32 DK007737NIEHS NIH HHS P42 ES027704NIEHS NIH HHS P42 ES031009NIGMS NIH HHS R01 GM141277NIGMS NIH HHS RM1 GM145416
6 · The paper itself

Abstract

Bile acids play key roles in nutrient uptake, inflammation, signaling, and microbiome composition. While previous bile acid analyses have primarily focused on profiling 5 canonical primary and secondary bile acids and their glycine and taurine amino acid-bile acid (AA-BA) conjugates, recent studies suggest that many other microbial conjugated bile acids (or MCBAs) exist. MCBAs are produced by the gut microbiota and serve as biomarkers, providing information about early disease onset and gut health. Here we analyzed 8 core bile acids synthetically conjugated with 22 proteinogenic and nonproteogenic amino acids totaling 176 MCBAs. Since many of the conjugates were isomeric and only 42 different

Indexed as

Amino AcidsBile Acids and SaltsAnimalsHumansIsomerismMass SpectrometryMiceSteroidsAmino AcidsBile Acids and SaltsSteroids

Identifiers

PMID37796494
PMCPMC10613829
OpenAlexW4387356866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.