ArticleAbdominal radiology (New York)2024
Optimal conspicuity of pancreatic ductal adenocarcinoma in virtual monochromatic imaging reconstructions on a photon-counting detector CT: comparison to conventional MDCT.
Article in Abdominal radiology (New York), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 33 citations in OpenAlex.
- Practical applications of photon-counting CT in oncology: an organ-based pictorial review.Insights into imaging · 2026Article
- Scan Range and Radiation Dose of the Ultra-High-Resolution Series in Pancreatic Photon-Counting Detector CT: A Prospective Two-Group Comparison of an Ultra-Low-Dose Planning Series.Diagnostics (Basel, Switzerland) · 2026Article
- A Practical Rule-of-Thumb to Adapt Contrast Media Dose in Photon-counting Detector CT: The 10-to-5 Rule.Investigative radiology · 2026Article
- Spectral CT in patients with colorectal cancer: quantitative contrast lesional assessment of mucinous and non-mucinous peritoneal metastases using virtual monoenergetic imaging.Abdominal radiology (New York) · 2026Article
- Seeing the invisible: practical strategies to maximize the clinical impact of photon-counting CT in abdominal imaging.Abdominal radiology (New York) · 2026Review
- Follow-up recommendation rates with abdominopelvic photon counting CT: comparison with conventional dual-energy and single-energy CT.Abdominal radiology (New York) · 2026Article
- Photon-counting CT for pancreatic cancer: advancing precision imaging and virtual surgical navigation.Journal of pancreatology · 2026Review
- Photon-counting detector CT in oncology: a new era of cancer imaging.Insights into imaging · 2026Review
- Multispectral PCCT and CBCT imaging for high precision radiotherapy through translation of imaging parameters with machine learning validation.Scientific reports · 2026Article
- Quantitative Conspicuity of Pancreatic Canine Insulinoma: A Comparison of Dynamic 4D CT and Dual-Source, Dual-Energy Bolus-Triggered Multiphase CT Imaging.Veterinary sciences · 2025Article
- Contrast medium dose optimization in the era of multi-energy CT.Japanese journal of radiology · 2025Review
- Optimizing photon counting CT enterography: determining the optimal virtual monoenergy for bowel imaging.Abdominal radiology (New York) · 2025Article
- Applications of photon-counting CT in oncologic imaging: A systematic review.World journal of radiology · 2025Article
- Potential of photon-counting detector CT technology for contrast medium reduction in portal venous phase thoracoabdominal CT.European radiology · 2025Article
- Optimal virtual monoenergy for the detection of pancreatic adenocarcinoma during the pancreatic parenchymal phase on photon counting CT.Abdominal radiology (New York) · 2025Article
- Advancements in early detection of pancreatic cancer: the role of artificial intelligence and novel imaging techniques.Abdominal radiology (New York) · 2025Review
- Photon-counting detector computed tomography: iodine density versus virtual monoenergetic imaging of pancreatic ductal adenocarcinoma.Abdominal radiology (New York) · 2025Article
- Performance of iodine quantification through high-pitch dual-source photon-counting CT: a phantom study.Japanese journal of radiology · 2025Article
- An update on pancreatic cancer imaging, staging, and use of the PACT-UK radiology template pre- and post-neoadjuvant treatment.The British journal of radiology · 2025Review
- Photon-counting CT: technical features and clinical impact on abdominal imaging.Abdominal radiology (New York) · 2024Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the conspicuity of pancreatic ductal adenocarcinoma (PDAC) in virtual monoenergetic images (VMI) on a novel photon-counting detector CT (PCD-CT) in comparison to energy-integrating CT (EID-CT).
methodsInclusion criteria comprised initial diagnosis of PDAC (reference standard: histopathological analysis) and standardized contrast-enhanced CT imaging either on an EID-CT or a PCD-CT. Patients were excluded due to different histopathological diagnosis or missing tumor delineation on CT. On the PCD-CT, 40-190 keV VMI reconstructions were generated. Image noise, tumor-to-pancreas ratio (TPR) and contrast-to-noise ratio (CNR) were analyzed by ROI-based measurements in arterial and portal venous contrast phase. Two board-certified radiologist evaluated image quality and tumor delineation at both, EID-CT and PCD-CT (40 and 70 keV).
resultsThirty-eight patients (mean age 70.4 years ± 10.3 [range 45-91], 27 males; PCD-CT: n=19, EID-CT: n=19) were retrospectively included. On the PCD-CT, tumor conspicuity (reflected by low TPR and high CNR) was significantly improved at low-energy VMI series (≤ 70 keV compared to > 70 keV), both in arterial and in portal venous contrast phase (P < 0.001), reaching the maximum at 40 keV. Comparison between PCD-CT and EID-CT showed significantly higher CNR on the PCD-CT in portal venous contrast phase at < 70 keV (P < 0.016). On the PCD-CT, tumor conspicuity was improved in portal venous contrast phase compared to arterial contrast phase especially at the lower end of the VMI spectrum (≤ 70 keV). Qualitative analysis revealed that tumor delineation is improved in 40 keV reconstructions compared to 70 keV reconstructions on a PCD-CT.
conclusionPCD-CT VMI reconstructions (≤ 70 keV) showed significantly improved conspicuity of PDAC in quantitative and qualitative analysis in both, arterial and portal venous contrast phase, compared to EID-CT, which may be important for early detection of tumor tissue in clinical routine. Tumor delineation was superior in portal venous contrast phase compared to arterial contrast phase.
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