Evidence map›Paper›PMID 37796306›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model.

Maria Meindl, Alexandra Bläske, Katja Steiger, Simon Lindner, Felix Lindheimer, Kirsten Lauber, Nikko Brix, Barbara von Ungern-Sternberg, Rosel Oos, Giovanna Palumbo and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Maria MeindlDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany. maria.meindl@med.uni-muenchen.de.
Alexandra BläskeDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Katja SteigerComparative Experimental Pathology, Institute of Pathology, TU Munich, Munich, Germany.
Simon LindnerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Felix LindheimerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Kirsten LauberDepartment of Radiotherapy and Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Nikko BrixDepartment of Radiotherapy and Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Barbara von Ungern-SternbergDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Rosel OosDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Giovanna PalumboDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Guido BöningDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Simone SchüleDepartment of Radiology, Bundeswehr Hospital, Ulm, Germany.
Matthäus MajewskiDepartment of Urology, Bundeswehr Hospital, Ulm, Germany.
Matthias PortBundeswehr Institute of Radiobiology, Munich, Germany.
Sibylle ZieglerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DEBundeswehrkrankenhaus · DEInstitut für Radiobiologie der Bundeswehr

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of therapy-induced injury to healthy tissue and the choice of adequate treatment of radiation emergency patients in both civilian and military events. This study aimed to investigate in a mouse model if positron emission tomography (PET) imaging with proliferation and apoptosis markers is potentially suitable for this purpose.

methodsFour groups, including twenty mice (wild-type C57BL/6) each, were whole-body irradiated with 0 Gy, 0.5 Gy, 1 Gy, and 3 Gy and examined by PET over a six-month period at defined time points. 3'-[

resultsThe hematopoietic bone marrow showed a significantly increased [

conclusion[

Indexed as

Positron-Emission TomographyWhole-Body IrradiationAnimalsApoptosisCell ProliferationDideoxynucleosidesDisease Models, AnimalHumansMiceMice, Inbred C57BLDideoxynucleosidesApoptosisIrradiationPETProliferation

Identifiers

PMID37796306
PMCPMC10774227
OpenAlexW4387357419

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.