ArticleArchives of orthopaedic and trauma surgery2024
Quantitative computed tomography has higher sensitivity detecting critical bone mineral density compared to dual-energy X-ray absorptiometry in postmenopausal women and elderly men with osteoporotic fractures: a real-life study.
Article in Archives of orthopaedic and trauma surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Comparative effectiveness of four techniques for identifying vertebral fragility fractures among elderly patients.European radiology · 2025Pooled it
- Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring.Advanced healthcare materials · 2026Review
- Lumbar spine DXA T-score and QCT BMD cutpoint values for defining osteofrailia among older men: a framework for further refinement.Skeletal radiology · 2026Review
- Calcium isotope ratio (δOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Prevalence and regional distribution of osteoporosis in adults aged 75 years and older: a quantitative computed tomography-based retrospective cross-sectional study.BMC geriatrics · 2026Article
- Criteria for osteoporosis diagnosis: a systematic review and meta-analysis of osteoporosis diagnostic studies with DXA and QCT.EClinicalMedicine · 2025Article
- The Role of ChatGPT in osteoporosis management: a comparative analysis with clinical expertise.Archives of osteoporosis · 2025Article
- Radiation Diagnostics of the Maxillofacial Region and Skeleton Bone Density in the Case of Vitamin D Insufficiency: A Pilot Study.Life (Basel, Switzerland) · 2025Article
- Undetected low bone mineral density in patients undergoing lumbar fusion surgery-prevalence and risk factors.North American Spine Society journal · 2025Article
- Comparative evaluation of accuracy, precision, and radiation dose between mindways and low-dose iCare QCT for lumbar spine BMD using the European spine phantom.Frontiers in medical technology · 2025Article
- Advancing osteoporosis diagnosis and fracture prediction: role of quantitative CT and future research directions.Archives of orthopaedic and trauma surgery · 2024Article
- Comparison of CT and MRI in diagnosing occult hip fracture: a systematic review and meta-analysis.American journal of translational research · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDual-energy X-ray absorptiometry (DXA) is considered the gold standard for the diagnosis of osteoporosis and assessment of fracture risk despite proven limitations. Quantitative computed tomography (QCT) is regarded as a sensitive method for diagnosis and follow-up. Pathologic fractures are classified as the main clinical manifestation of osteoporosis. The objective of the study was to compare DXA and QCT to determine their sensitivity and discriminatory power. MATERIALS AND
methodsPatients aged 50 years and older were included who had DXA of the lumbar spine and femur and additional QCT of the lumbar spine within 365 days. Fractures and bone mineral density (BMD) were retrospectively examined. BMD measurements were analyzed for the detection of osteoporotic fractures. Sensitivity and receiver operating characteristic curve were used for calculations. As an indication for a second radiological examination was given, the results were compared with control groups receiving exclusively DXA or QCT for diagnosis or follow-up.
resultsOverall, BMD measurements of 404 subjects were analyzed. DXA detected 15 (13.2%) patients having pathologic fractures (n = 114) with normal bone density, 66 (57.9%) with osteopenia, and 33 (28.9%) with osteoporosis. QCT categorized no patients having pathologic fractures with healthy bone density, 14 (12.3%) with osteopenia, and 100 (87.7%) with osteoporosis. T-score DXA, trabecular BMD QCT, and cortical BMD QCT correlated weakly. Trabecular BMD QCT and cortical BMD QCT classified osteoporosis with decreased bone mineral density (AUC 0.680; 95% CI 0.618-0.743 and AUC 0.617; 95% CI 0.553-0.682, respectively). T-score DXA could not predict prevalent pathologic fractures. In control groups, each consisting of 50 patients, DXA and QCT were significant classifiers to predict prevalent pathologic fractures.
conclusionOur results support that volumetric measurements by QCT in preselected subjects represent a more sensitive method for the diagnosis of osteoporosis and prediction of fractures compared to DXA.
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