ArticleeLife2023
Thalamic regulation of ocular dominance plasticity in adult visual cortex.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Advances in behavioral vision training for the treatment of childhood amblyopia: a narrative review.Translational pediatrics · 2026Review
- Specific Neural Mechanisms Underlying Humans' Processing of Information Related to Companion Animals: A Comparison with Domestic Animals and Objects.Animals : an open access journal from MDPI · 2025Article
- Article
- Experience influences the refinement of feature selectivity in the mouse primary visual thalamus.Neuron · 2025Article
- Association of aberrant brain network connectivity with visual dysfunction in patients with nonarteritic anterior ischemic optic neuropathy: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experience-dependent plasticity in the adult visual system is generally thought of as a cortical process. However, several recent studies have shown that perceptual learning or monocular deprivation can also induce plasticity in the adult dorsolateral geniculate nucleus (dLGN) of the thalamus. How plasticity in the thalamus and cortex interact in the adult visual system is ill-understood. To assess the influence of thalamic plasticity on plasticity in primary visual cortex (V1), we made use of our previous finding that during the critical period ocular dominance (OD) plasticity occurs in dLGN and requires thalamic synaptic inhibition. Using multielectrode recordings we find that this is also true in adult mice, and that in the absence of thalamic inhibition and plasticity, OD plasticity in adult V1 is absent. To study the influence of V1 on thalamic plasticity, we silenced V1 and show that during the critical period, but not in adulthood, the OD shift in dLGN is partially caused by feedback from V1. We conclude that during adulthood the thalamus plays an unexpectedly dominant role in experience-dependent plasticity in V1. Our findings highlight the importance of considering the thalamus as a potential source of plasticity in learning events that are typically thought of as cortical processes.
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