Evidence map›Paper›PMID 37796143›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2023

Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment.

Christopher Kuo, James F Amatruda

Open access · greenAbstract readComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher KuoCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California.ORCID 0000-0002-6222-147X
James F AmatrudaCancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California.ORCID 0000-0002-9901-2137
University of Southern California · US

Funding

Targeting EWSR1-FLI1 through Functional, Structural and Chemical ApproachesU54CA231649 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI AMATRUDA, JAMES F, MCFADDEN, DAVID GLENN · 2019 to 2019
$10.0M
Technical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ LevelU54CA268072 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Reto Paul Fiolka · 2021 to 2026
$9.1M
NCI NIH HHS U54 CA231649NCI NIH HHS U54 CA268072
6 · The paper itself

Abstract

Cells in the tumor microenvironment, including cancer-associated fibroblasts (CAF), contribute to tumor growth and immune evasion. A recent study of Ewing sarcoma identified "CAF-like" tumor cells that mimic the protumorigenic features of CAFs. These findings highlight the role of cell plasticity in tumor growth. See related article by Wrenn et al., p. 5140.

Indexed as

Cancer-Associated FibroblastsSarcoma, EwingFibroblastsHumansSoilTumor MicroenvironmentSoil

Identifiers

PMID37796143
PMCPMC10873080
OpenAlexW4387356803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.