Evidence map›Paper›PMID 37795995›Full record

ArticleGut microbes2023

Colorectal cancer-associated T cell receptor repertoire abnormalities are linked to gut microbiome shifts and somatic cell mutations.

Yuan Cao, Jifeng Wang, Weiliang Hou, Yanqiang Ding, Yefei Zhu, Jiayi Zheng, Qiongyi Huang, Zhan Cao, Ruting Xie, Qing Wei and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Yuan CaoDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Jifeng WangDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Weiliang HouResearch Institute of Intestinal Diseases, Tongji University School of Medicine, Shanghai, China.
Yanqiang DingInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yefei ZhuResearch Institute of Intestinal Diseases, Tongji University School of Medicine, Shanghai, China.
Jiayi ZhengDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Qiongyi HuangDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Zhan CaoShanghai Institution of Gut Microbiota Research and Engineering Development, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Ruting XieDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Qing WeiDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.ORCID 0000-0002-9007-5473
Huanlong QinDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Tongji University · CNChinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As with many diseases, tumor formation in colorectal cancer (CRC) is multifactorial and involves immune, environmental factors and various genetics that contribute to disease development. Accumulating evidence suggests that the gut microbiome is linked to the occurrence and development of CRC, and these microorganisms are important for immune maturation. However, a systematic perspective integrating microbial profiling, T cell receptor (TCR) and somatic mutations in humans with CRC is lacking. Here, we report distinct features of the expressed TCRβ repertoires in the peripheral blood of and CRC patients (

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeBiomarkersFusobacterium nucleatumHumansMutationReceptors, Antigen, T-CellBiomarkersReceptors, Antigen, T-CellCRCFusobacterium nucleatumgut microbiotasomatic mutationsTCR

Identifiers

PMID37795995
PMCPMC10557533
OpenAlexW4387357431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.