Evidence map›Paper›PMID 37795833›Full record

ReviewCNS neuroscience & therapeutics2024

How inflammation dictates diabetic peripheral neuropathy: An enlightening review.

Yifan Cheng, Yinuo Chen, Kezheng Li, Shuwei Liu, Chunyang Pang, Lingfei Gao, Jiali Xie, L V Wenjing, Huan Yu, Binbin Deng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yifan ChengCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Yinuo ChenDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Kezheng LiDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Shuwei LiuFirst School of Clinical Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Chunyang PangDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Lingfei GaoDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Jiali XieDepartment of Neurology, Shanghai East Hospital, Tongji University, Shanghai, P.R. China.
L V WenjingDepartment of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
Huan YuDepartment of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Binbin DengDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.ORCID 0000-0002-4058-0738

Funding

Medical Science and Technology Project of Zhejiang Province 2022KY506National Natural Science Foundation of China 81901273Science Technology Department of Zhejiang Province Q21H090076
6 · The paper itself

Abstract

backgroundDiabetic peripheral neuropathy (DPN) constitutes a debilitating complication associated with diabetes. Although, the past decade has seen rapid developments in understanding the complex etiology of DPN, there are no approved therapies that can halt the development of DPN, or target the damaged nerve. Therefore, clarifying the pathogenesis of DPN and finding effective treatment are the crucial issues for the clinical management of DPN.

aimsThis review is aiming to summary the current knowledge on the pathogenesis of DPN, especially the mechanism and application of inflammatory response.

methodsWe systematically summarized the latest studies on the pathogenesis and therapeutic strategies of diabetic neuropathy in PubMed.

resultsIn this seminal review, the underappreciated role of immune activation in the progression of DPN is scrutinized. Novel insights into the inflammatory regulatory mechanisms of DPN have been unearthed, illuminating potential therapeutic strategies of notable clinical significance. Additionally, a nuanced examination of DPN's complex etiology, including aberrations in glycemic control and insulin signaling pathways, is presented. Crucially, an emphasis has been placed on translating these novel understandings into tangible clinical interventions to ameliorate patient outcomes.

conclusionsThis review is distinguished by synthesizing cutting-edge mechanisms linking inflammation to DPN and identifying innovative, inflammation-targeted therapeutic approaches.

Indexed as

Diabetes MellitusDiabetic NeuropathiesHumansInflammationInsulinSignal TransductionTreatment OutcomeInsulindiabetic neuropathyinflammatory responsemetabolic changesmolecular mechanism

Identifiers

PMID37795833
PMCPMC11017439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.