ArticleDevelopment (Cambridge, England)2023
A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.
Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Making Sense of Developmental Kinetics Under High-Sugar Stress: Mathematical Modeling of Phenotypic Plasticity inNutrients · 2026Article
- Article
- Metformin modulates survival, oxidative stress, and gene expression in a high-sucrose Drosophila diabetes model.PloS one · 2026Article
- Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance.Developmental biology · 2025Article
- Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila.Biogerontology · 2025Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Adipocyte-DerivedBiomolecules · 2025Article
- Association of dietary preferences with primary ovarian insufficiency (POI): a mendelian randomization-based analysis.BMC women's health · 2024Article
- High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster.PLoS pathogens · 2024Article
- Article
- Integrating the dynamic and energetic fields of metabolism and development.Development (Cambridge, England) · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is linked to reduced fertility in various species, from Drosophila to humans. Considering that obesity is often induced by changes in diet or eating behavior, it remains unclear whether obesity, diet, or both reduce fertility. Here, we show that Drosophila females on a high-sugar diet become rapidly obese and less fertile as a result of increased death of early germline cysts and vitellogenic egg chambers (or follicles). They also have high glycogen, glucose and trehalose levels and develop insulin resistance in their fat bodies (but not ovaries). By contrast, females with adipocyte-specific knockdown of the anti-obesity genes brummer or adipose are obese but have normal fertility. Remarkably, females on a high-sugar diet supplemented with a separate source of water have mostly normal fertility and glucose levels, despite persistent obesity, high glycogen and trehalose levels, and fat body insulin resistance. These findings demonstrate that a high-sugar diet affects specific processes in oogenesis independently of insulin resistance, that high glucose levels correlate with reduced fertility on a high-sugar diet, and that obesity alone does not impair fertility.
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