Evidence map›Paper›PMID 37795688›Full record

ArticlePsychological medicine2023

Do general and specific factors of preschool psychopathology predict preadolescent outcomes? A transdiagnostic hierarchical approach.

Giorgia Michelini, Kelly Gair, Yuan Tian, Jiaju Miao, Lea R Dougherty, Brandon L Goldstein, Leigha A MacNeill, Deanna M Barch, Joan L Luby, Lauren S Wakschlag and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. It's not just what you have, but when: The role and timing of developmental assets in the mental health of young adults.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Giorgia MicheliniDepartment of Biological & Experimental Psychology, School of Biological & Behavioural Sciences, Queen Mary University of London, London, UK.ORCID 0000-0002-0887-7582
Kelly GairDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
Yuan TianDepartment of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
Jiaju MiaoDepartment of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
Lea R DoughertyDepartment of Psychology, University of Maryland, College Park, MD, USA.
Brandon L GoldsteinDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Leigha A MacNeillDepartment of Medical Social Sciences, Feinberg School of Medicine, and Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, USA.
Deanna M BarchDepartments of Psychological & Brain Sciences, Washington University, St. Louis, MO, USA.
Joan L LubyDepartments of Psychiatry, Washington University, St. Louis, MO, USA.
Lauren S WakschlagDepartment of Medical Social Sciences, Feinberg School of Medicine, and Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, USA.
Daniel N KleinDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
Roman KotovDepartment of Psychiatry & Behavioral Health, Stony Brook University, Stony Brook, NY, USA.
Stony Brook University · USNorthwestern University · USWashington University in St. Louis · USUniversity of California, Los Angeles · USUniversity of Connecticut · USUniversity of Maryland, College Park · US

Funding

Temperamental Low PE in Preschoolers and Depression RiskR01MH069942 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI KLEIN, DANIEL N · 2004 to 2023
$14.2M
Optimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approachR01MH121877 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUBY, JOAN L., ROGERS, CYNTHIA ELISE · 2020 to 2024
$8.2M
Validation of Preschool Depressive SyndromeR01MH064769 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2003 to 2012
$7.7M
Dimensions of Early Temper Loss and Low Concern: Clinical Utility and MechanismsU01MH082830 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2014 to 2018
$3.9M
Developmental Characterization of Preschool Disruptive BehaviorR01MH082830 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2009 to 2013
$3.7M
Early Traumatic Stress Exposure: Neurodevelopmental Mechanisms of Clinical RiskU01MH090301 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRIGGS-GOWAN, MARGARET J · 2012 to 2014
$2.4M
NIH HHS U01MH090301NIMH NIH HHS R01 MH064769NIMH NIH HHS R01 MH069942NIMH NIH HHS R01 MH082830NIMH NIH HHS R01 MH121877NIMH NIH HHS U01 MH082830NIMH NIH HHS U01 MH090301
6 · The paper itself

Abstract

backgroundPreschool psychiatric symptoms significantly increase the risk for long-term negative outcomes. Transdiagnostic hierarchical approaches that capture general ('p') and specific psychopathology dimensions are promising for understanding risk and predicting outcomes, but their predictive utility in young children is not well established. We delineated a hierarchical structure of preschool psychopathology dimensions and tested their ability to predict psychiatric disorders and functional impairment in preadolescence.

methodsData for 1253 preschool children (mean age = 4.17, s.d. = 0.81) were drawn from three longitudinal studies using a similar methodology (one community sample, two psychopathology-enriched samples) and followed up into preadolescence, yielding a large and diverse sample. Exploratory factor models derived a hierarchical structure of general and specific factors using symptoms from the Preschool Age Psychiatric Assessment interview. Longitudinal analyses examined the prospective associations of preschool

resultsA hierarchical dimensional structure with a

conclusionsBoth general and specific dimensions of preschool psychopathology are useful for predicting clinical and functional outcomes almost a decade later. These findings highlight the value of transdiagnostic dimensions for predicting prognosis and as potential targets for early intervention and prevention.

Indexed as

Mental DisordersPsychopathologyChild, PreschoolFearHumansp factorpreadolescencepredictive utilityPreschoolspecific dimensiontransdiagnostic dimension

Identifiers

PMID37795688
PMCPMC10482704
OpenAlexW4292849649

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.