Evidence map›Paper›PMID 37795593›Full record

ArticleStroke2023

Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke.

Mercy H Mazurek, Nethra R Parasuram, Teng J Peng, Rachel Beekman, Vineetha Yadlapalli, Annabel J Sorby-Adams, Dheeraj Lalwani, Julia Zabinska, Emily J Gilmore, Nils H Petersen and 11 more

Open access · greenAbstract read
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Portable Bedside Low-Field MRI for Assessment of Ventricular Size.AJNR. American journal of neuroradiology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Engineering Principles and Bioengineering in Global Health.Neurosurgery clinics of North America · 2024
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Mercy H MazurekDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0002-4655-4266
Nethra R ParasuramDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.
Teng J PengDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0002-0576-1402
Rachel BeekmanDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0002-7870-6762
Vineetha YadlapalliDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0002-6241-7130
Annabel J Sorby-AdamsDivision of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston (A.J.S.-A., W.T.K.).
Dheeraj LalwaniDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.
Julia ZabinskaDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.
Emily J GilmoreDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.
Nils H PetersenDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0001-9711-3340
Guido J FalconeDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0002-6407-0302
Nanthiya SujijantaratDepartment of Neurosurgery (N.S., C.M., S.J.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0002-5857-5718
Charles MatoukDepartment of Neurosurgery (N.S., C.M., S.J.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0003-3234-9541
Sam PayabvashDepartment of Radiology, Yale University School of Medicine, New Haven, CT (S.P., G.S.).ORCID 0000-0003-4628-0370
Gordon SzeDepartment of Radiology, Yale University School of Medicine, New Haven, CT (S.P., G.S.).
Steven J SchiffYale Center for Brain & Mind Health (S.J.S., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0003-2623-3614
Juan Eugenio IglesiasCentre for Medical Image Computing, University College London, United Kingdom (J.E.I.).
Adam de HavenonDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0001-8178-8597
W Taylor KimberlyDivision of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston (A.J.S.-A., W.T.K.).ORCID 0000-0002-2519-8530
Kevin N ShethDepartment of Neurology (M.H.M., N.R.P., T.J.P., R.B., V.Y., D.L., J.Z., E.J.G., N.H.P., G.J.F., A.d.H., K.N.S.), Yale School of Medicine, New Haven, CT.ORCID 0000-0003-2003-5473
RCA (United States) · USYale University · USMassachusetts General Hospital · USArtificial Intelligence in Medicine (Canada) · CAAthinoula A. Martinos Center for Biomedical Imaging · US

Funding

Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
Neurocognitive outcomes and changes in brain and CSF volume after treatment of post-infectious hydrocephalus in Ugandan infants by shunting or ETV/CPC: a randomized prospective trialR01HD085853 · NICHD · YALE UNIVERSITY · PI KULKARNI, ABHAYA V, SCHIFF, STEVEN JOHN · 2015 to 2025
$4.7M
Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute StrokeR01EB031114 · NIBIB · YALE UNIVERSITY · PI William Taylor Kimberly, Matthew Scot Rosen · 2022 to 2026
$3.5M
Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
Yale-METRO Metropolitan Emergency Trial netwoRK to advance patient OutcomesU24NS129500 · NINDS · YALE UNIVERSITY · PI Gail D'Onofrio, Kevin Navin Sheth · 2023 to 2026
$1.7M
Yale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7M
Precision blood pressure management after endovascular stroke therapy based on real-time autoregulation measurementsK23NS110980 · NINDS · YALE UNIVERSITY · PI PETERSEN, NILS H. · 2020 to 2024
$951k
NIBIB NIH HHS R01 EB031114NICHD NIH HHS R01 HD085853NINDS NIH HHS K23 NS110980NINDS NIH HHS U01 NS106513NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINDS NIH HHS U24 NS129500
6 · The paper itself

Abstract

backgroundNeuroimaging is essential for detecting spontaneous, nontraumatic intracerebral hemorrhage (ICH). Recent data suggest ICH can be characterized using low-field magnetic resonance imaging (MRI). Our primary objective was to investigate the sensitivity and specificity of ICH on a 0.064T portable MRI (pMRI) scanner using a methodology that provided clinical information to inform rater interpretations. As a secondary aim, we investigated whether the incorporation of a deep learning (DL) reconstruction algorithm affected ICH detection.

methodsThe pMRI device was deployed at Yale New Haven Hospital to examine patients presenting with stroke symptoms from October 26, 2020 to February 21, 2022. Three raters independently evaluated pMRI examinations. Raters were provided the images alongside the patient's clinical information to simulate real-world context of use. Ground truth was the closest conventional computed tomography or 1.5/3T MRI. Sensitivity and specificity results were grouped by DL and non-DL software to investigate the effects of software advances.

resultsA total of 189 exams (38 ICH, 89 acute ischemic stroke, 8 subarachnoid hemorrhage, 3 primary intraventricular hemorrhage, 51 no intracranial abnormality) were evaluated. Exams were correctly classified as positive or negative for ICH in 185 of 189 cases (97.9% overall accuracy). ICH was correctly detected in 35 of 38 cases (92.1% sensitivity). Ischemic stroke and no intracranial abnormality cases were correctly identified as blood-negative in 139 of 140 cases (99.3% specificity). Non-DL scans had a sensitivity and specificity for ICH of 77.8% and 97.1%, respectively. DL scans had a sensitivity and specificity for ICH of 96.6% and 99.3%, respectively.

conclusionsThese results demonstrate improvements in ICH detection accuracy on pMRI that may be attributed to the integration of clinical information in rater review and the incorporation of a DL-based algorithm. The use of pMRI holds promise in providing diagnostic neuroimaging for patients with ICH.

Indexed as

Ischemic StrokeStrokeCerebral HemorrhageHumansMagnetic Resonance ImagingTomography, X-Ray Computedcerebral hemorrhagemagnetic resonance imagingneuroimagingstroketomography

Identifiers

PMID37795593
PMCPMC11103256
OpenAlexW4387357241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.