Evidence map›Paper›PMID 37795500›Full record

ArticleNeurology. Clinical practice2023

Recovery of Acute Leukoencephalopathy Documented by Neuroimaging: A Case Report.

Emilie Szymkowicz, Olga Neumann, Leandro R D Sanz, Olivia Gosseries, Aurore Thibaut, Carlo Cavaliere, Steven Laureys, Joachim Liepert

Erratum issuedOpen access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Erratum: Missing Full Disclosures.Neurology. Clinical practice · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Emilie SzymkowiczComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0002-2247-515X
Olga NeumannComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0009-0009-1985-9695
Leandro R D SanzComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0001-5054-2471
Olivia GosseriesComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0001-9011-7496
Aurore ThibautComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0001-5991-1747
Carlo CavaliereComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0002-3297-2213
Steven LaureysComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0002-3096-3807
Joachim LiepertComa Science Group (ES, LRS, OG, AT, SL), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (ES, LRDS, OG, AT, SL), University Hospital of Liège, Belgium; Kliniken Schmieder (ON, JL), Allensbach, Germany; and IRCCS SYNLAB SDN (CC), Naples, Italy.ORCID https://orcid.org/0000-0002-1383-2346
Synlab Czech (Czechia) · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: We describe an atypical delayed neurologic recovery from coma and unresponsive wakefulness syndrome (i.e., persistent vegetative state) in a patient with severe drug-induced toxic leukoencephalopathy (presumably due to synthetic cannabinoid intake). Methods: The patient underwent standardized behavioral and multimodal neuroimaging assessments to monitor clinical evolution and brain function over a 5-month period after presumed intoxication. Results: A progressive clinical recovery was observed, from an initial state of coma to emergence from a minimally conscious state after 2 months. Despite the stability of extensive white matter lesions documented by CT and structural MRI, fluorodeoxyglucose PET showed partial recovery of cortical metabolism after 5 months. Discussion: This case report illustrates that the temporal dynamics of recovery from toxic acute leukoencephalopathy may be atypical and delayed. Multimodal monitoring with repeated behavioral and functional neuroimaging assessments tends to improve the prognosis reliability, while early prognosis based on structural damage may result in misleading statements.

Identifiers

PMID37795500
PMCPMC10547467
OpenAlexW4387312647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.