ArticleFrontiers in neuroscience2023
Human deprivation amblyopia: treatment insights from animal models.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Dose-Response Characteristics of Retinal Inactivation Due to Intravitreal Injections of Tetrodotoxin in Nonhuman Primates.Investigative ophthalmology & visual science · 2026Article
- The effects of unilateral deprivation amblyopia on fixation stability.Frontiers in neuroscience · 2026Article
- The influence of prior brief occlusion therapy on the outcome of later amblyopia treatment in cats.Frontiers in neuroscience · 2026Article
- Loss and recovery of neurofilament in the cat lateral geniculate nucleus following monocular retinal inactivation.Frontiers in neuroscience · 2026Article
- Temporary retinal inactivation reverses effects of long-term monocular deprivation in visual cortex by induction of burst mode firing in the thalamus.Cell reports · 2025Article
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Childhood amblyopia in a tertiary eye care center in western India.International journal of ophthalmology · 2025Article
- Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children.iScience · 2024Article
- Phenotypic Features Determining Visual Acuity in Albinism and the Role of Amblyogenic Factors.Investigative ophthalmology & visual science · 2024Article
- Clinical ocular prediction model of postoperative ametropic amblyopia in patients with congenital ectopia lentis.Frontiers in medicine · 2024Article
- Acceleration of spontaneous visual recovery by voluntary physical exercise in adolescent amblyopic rats.Frontiers in cellular neuroscience · 2024Article
- Leveraging neural plasticity for the treatment of amblyopia.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Amblyopia is a common visual impairment that develops during the early years of postnatal life. It emerges as a sequela to eye misalignment, an imbalanced refractive state, or obstruction to form vision. All of these conditions prevent normal vision and derail the typical development of neural connections within the visual system. Among the subtypes of amblyopia, the most debilitating and recalcitrant to treatment is deprivation amblyopia. Nevertheless, human studies focused on advancing the standard of care for amblyopia have largely avoided recruitment of patients with this rare but severe impairment subtype. In this review, we delineate characteristics of deprivation amblyopia and underscore the critical need for new and more effective therapy. Animal models offer a unique opportunity to address this unmet need by enabling the development of unconventional and potent amblyopia therapies that cannot be pioneered in humans. Insights derived from studies using animal models are discussed as potential therapeutic innovations for the remediation of deprivation amblyopia. Retinal inactivation is highlighted as an emerging therapy that exhibits efficacy against the effects of monocular deprivation at ages when conventional therapy is ineffective, and recovery occurs without apparent detriment to the treated eye.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.