Evidence map›Paper›PMID 37795179›Full record

ArticleNeuro-oncology advances

MRI-guided focused ultrasound blood-brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model.

Payton Martinez, Genna Nault, Jenna Steiner, Michael F Wempe, Angela Pierce, Breauna Brunt, Mathew Slade, Jane J Song, Andrew Mongin, Kang-Ho Song and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  12. Focused ultrasound in pediatric neurosurgery: a scoping review of opportunities and challenges.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
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  17. Frequency-Selective Microbubble TargetingACS applied bio materials · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Payton MartinezBiomedical Engineering Program, University of Colorado Boulder, Boulder, Colorado, USA.
Genna NaultDepartment of Radiology, Animal Imaging Shared Resource, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jenna SteinerDepartment of Radiology, Animal Imaging Shared Resource, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Michael F WempeDepartment of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Angela PierceMorgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Breauna BruntMorgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Mathew SladeMorgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jane J SongBiomedical Engineering Program, University of Colorado Boulder, Boulder, Colorado, USA.
Andrew MonginBiomedical Engineering Program, University of Colorado Boulder, Boulder, Colorado, USA.
Kang-Ho SongDepartment of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, USA.
Nicholas EllensAlpheus Medical, Inc., Chanhassen, Minnesota, USA.
Natalie SerkovaDepartment of Radiology, Animal Imaging Shared Resource, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Adam L GreenMorgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Mark BordenBiomedical Engineering Program, University of Colorado Boulder, Boulder, Colorado, USA.ORCID https://orcid.org/0000-0002-2089-983X
University of Colorado Boulder · USMorgan Adams Foundation · USUniversity of Colorado Anschutz Medical Campus · USAcoustics Research Institute · AT

Funding

Microbubble Dose Optimization for Image-Guided Drug DeliveryR01CA239465 · NCI · UNIVERSITY OF COLORADO · PI BORDEN, MARK ANDREW · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA239465
6 · The paper itself

Abstract

Background: Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest pediatric brainstem tumor and is difficult to treat with chemotherapy in part due to the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubbles (MBs) have been shown to cause BBB opening, allowing larger chemotherapeutics to enter the parenchyma. Panobinostat is an example of a promising in vitro agent in DIPG with poor clinical efficacy due to low BBB penetrance. In this study, we hypothesized that using FUS to disrupt the BBB allows higher concentrations of panobinostat to accumulate in the tumor, providing a therapeutic effect. Methods: Mice were orthotopically injected with a patient-derived diffuse midline glioma (DMG) cell line, BT245. MRI was used to guide FUS/MB (1.5 MHz, 0.615 MPa peak negative pressure, 1 Hz pulse repetition frequency, 10-ms pulse length, 3 min treatment time)/(25 µL/kg, i.v.) targeting to the tumor location. Results: In animals receiving panobinostat (10 mg/kg, i.p.) in combination with FUS/MB, a 3-fold increase in tumor panobinostat concentration was observed, without significant increase of the drug in the forebrain. In mice receiving 3 weekly treatments, the combination of panobinostat and FUS/MB led to a 71% reduction of tumor volumes ( Conclusions: Our study demonstrates that FUS-mediated BBB disruption can increase the delivery of panobinostat to an orthotopic DMG tumor, providing a strong therapeutic effect and increased survival.

Indexed as

blood–brain barrier openingdiffuse midline gliomasdrug deliveryfocused ultrasoundmicrobubbles

Identifiers

PMID37795179
PMCPMC10547466
OpenAlexW4386942071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.