Evidence map›Paper›PMID 37795132›Full record

ArticleSynOpen (2017)2023

Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery.

Derek A Leas, Daniel C Schultz, Robert W Huigens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SynOpen (2017), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Derek A LeasDepartment of Medicinal Chemistry, Center for Natural Products Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Daniel C SchultzDepartment of Medicinal Chemistry, Center for Natural Products Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0002-7727-9148
Robert W HuigensDepartment of Medicinal Chemistry, Center for Natural Products Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0003-3811-2721
American Association of Colleges of Pharmacy · US

Funding

Indole Alkaloids and Phenazine Antibiotics: New Platforms for Drug DiscoveryR35GM128621 · NIGMS · UNIVERSITY OF FLORIDA · PI HUIGENS, ROBERT WILLIAM · 2018 to 2022
$1.7M
Team-based Interdisciplinary Cancer Research Training ProgramT32CA257923 · NCI · UNIVERSITY OF FLORIDA · PI SIEMANN, DIETMAR W · 2021 to 2025
$1.2M
NCI NIH HHS T32 CA257923NIGMS NIH HHS R35 GM128621
6 · The paper itself

Abstract

This graphical review provides a concise overview of indole alkaloids and chemical reactions that have been reported to transform both these natural products and derivatives to rapidly access new molecular scaffolds. Select biologically active compounds from these synthetic efforts are reported herein.

Indexed as

chemical synthesisindole alkaloidsreserpinering distortionvincamineyohimbine

Identifiers

PMID37795132
PMCPMC10549995
OpenAlexW4323350147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.