Evidence map›Paper›PMID 37795086›Full record

ReviewFrontiers in immunology2023

Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies.

Phillip L Marsh, Ernest E Moore, Hunter B Moore, Connor M Bunch, Michael Aboukhaled, Shaun M Condon, Mahmoud D Al-Fadhl, Samuel J Thomas, John R Larson, Charles W Bower and 29 more

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  13. Bedside manufacturing of engineered stem cells using gene therapy foam.Molecular therapy. Methods & clinical development · 2025
    Article
  14. Review
  15. Article
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  18. Air embolism: The unknown story in ritual animal slaughter.The Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors at 10 institutions in 2 countries.

Phillip L MarshDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Ernest E MooreDepartment of Surgery, Ernest E. Moore Shock Trauma Center at Denver Health and University of Colorado Health Sciences Center, Denver, CO, United States.
Hunter B MooreUniversity of Colorado Health Transplant Surgery - Anschutz Medical Campus, Aurora, CO, United States.
Connor M BunchDepartment of Emergency Medicine, Henry Ford Hospital, Detroit, MI, United States.
Michael AboukhaledDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Shaun M CondonDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Mahmoud D Al-FadhlIndiana University School of Medicine, South Bend, IN, United States.
Samuel J ThomasDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
John R LarsonDepartment of Emergency Medicine, Goshen Health, Goshen, IN, United States.
Charles W BowerDepartment of Emergency Medicine, Goshen Health, Goshen, IN, United States.
Craig B MillerDepartment of Family Medicine, Saint Joseph Health System, Mishawaka, IN, United States.
Michelle L PearsonDepartment of Family Medicine, Saint Joseph Health System, Mishawaka, IN, United States.
Christopher L TwillingDepartment of Family Medicine, Saint Joseph Health System, Mishawaka, IN, United States.
David W ReserDepartment of Emergency Medicine, Goshen Health, Goshen, IN, United States.
George S KimDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Brittany M TroyerDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Doyle YeagerDepartment of Emergency Medicine, Goshen Health, Goshen, IN, United States.
Scott G ThomasDepartment of Trauma & Surgical Research Services, South Bend, IN, United States.
Daniel P SrikurejaDepartment of Trauma & Surgical Research Services, South Bend, IN, United States.
Shivani S PatelDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Sofía L AñónDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Anthony V ThomasIndiana University School of Medicine, South Bend, IN, United States.
Joseph B MillerDepartment of Emergency Medicine, Henry Ford Hospital, Detroit, MI, United States.
David E Van RynDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Saagar V PamulapatiDepartment of Internal Medicine, Mercy Health Internal Medicine Residency Program, Rockford, IL, United States.
Devin ZimmermanDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Byars WellsDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Peter L MartinDepartment of Emergency Medicine, Goshen Health, Goshen, IN, United States.
Christopher W SederDepartment of Cardiovascular and Thoracic Surgery, RUSH Medical College, Chicago, IL, United States.
John G AversaDepartment of Cardiovascular and Thoracic Surgery, RUSH Medical College, Chicago, IL, United States.
Ryan B GreeneDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Robert J MarchDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Hau C KwaanDivision of Hematology and Oncology, Department of Medicine, Northwestern University, Chicago, IL, United States.
Daniel H FulkersonDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
Stefani A Vande LuneDepartment of Emergency Medicine, Naval Medical Center Portsmouth, Portsmouth, VA, United States.
Tom E MollnesResearch Laboratory, Nordland Hospital, Bodø, Norway.
Erik W NielsenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Benjamin S StormDepartment of Anesthesia and Intensive Care Medicine, Surgical Clinic, Nordland Hospital, Bodø, Norway.
Mark M WalshDepartment of Emergency Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN, United States.
St. Joseph Regional Medical Center · USGoshen Health · USHenry Ford Hospital · USIndiana University School of MedicineUiT The Arctic University of Norway · NOUniversity of Colorado Health · USMercy Health · USNaval Medical Center Portsmouth · USNorthwestern University · USOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iatrogenic vascular air embolism is a relatively infrequent event but is associated with significant morbidity and mortality. These emboli can arise in many clinical settings such as neurosurgery, cardiac surgery, and liver transplantation, but more recently, endoscopy, hemodialysis, thoracentesis, tissue biopsy, angiography, and central and peripheral venous access and removal have overtaken surgery and trauma as significant causes of vascular air embolism. The true incidence may be greater since many of these air emboli are asymptomatic and frequently go undiagnosed or unreported. Due to the rarity of vascular air embolism and because of the many manifestations, diagnoses can be difficult and require immediate therapeutic intervention. An iatrogenic air embolism can result in both venous and arterial emboli whose anatomic locations dictate the clinical course. Most clinically significant iatrogenic air emboli are caused by arterial obstruction of small vessels because the pulmonary gas exchange filters the more frequent, smaller volume bubbles that gain access to the venous circulation. However, there is a subset of patients with venous air emboli caused by larger volumes of air who present with more protean manifestations. There have been significant gains in the understanding of the interactions of fluid dynamics, hemostasis, and inflammation caused by air emboli due to

Indexed as

Embolism, AirThrombosisHumansIatrogenic DiseaseInflammationThromboinflammationair embolismarteriolesdecompression sicknesshyperbaric oxygenationmicrobubblesthromboinflammation

Identifiers

PMID37795086
PMCPMC10546929
OpenAlexW4386893585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.