ArticleJournal of the American Geriatrics Society2024
Pain and incident cognitive impairment in very old Mexican American adults.
Article in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Pain, sleep complaints, and depressive symptom clusters and their association with cognitive decline in older Mexican Americans.BMC geriatrics · 2026Article
- Associations between pain and cognitive impairment in older adults: findings from the birjand longitudinal aging study.Aging clinical and experimental research · 2026Article
- Considerations for a Mind-Body Program for Latine Adults with Chronic Pain and Cognitive Impairment: A Qualitative Study with Healthcare Providers.Journal of pain research · 2026Article
- High-impact chronic pain and cognitive decline among Mexicans aged 60 and older from 2012 to 2018.The journal of pain · 2025Article
- Chronic pain in the Chilean population: risk factors prevalence and cognitive associations.Frontiers in aging · 2025Article
- Preoperative geriatric nutritional risk index as a predictor of postoperative delirium in revision arthroplasty: a 10-year retrospective cohort study.Frontiers in medicine · 2025Article
- Association between nutrition literacy and cognitive impairment among older adults in Bengbu, China.Frontiers in aging neuroscience · 2025Article
- Association between pain interference and motoric cognitive risk syndrome in older adults: a population-based cohort study.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies have investigated the association between pain and cognitive impairment among older adults, but the findings are mixed. We assessed the relationship of activity-limiting pain (pain interference) with incident cognitive impairment and the mediating effect of depressive symptoms among Mexican American adults aged ≥80.
methodsData were taken from the Hispanic Established Population for the Epidemiological Study of the Elderly (2010-2016). Pain interference, or pain that limited daily activities in the last 12 months, was categorized into none, untreated pain interference, and treated pain interference. Cognitive impairment was defined as scoring <21 on the Mini-Mental State Examination and difficulty with at least one instrumental activity of daily living. We used general estimation equations to assess this relationship between pain and incident cognitive impairment over the 6-year period (n = 313).
resultsParticipants reporting both untreated and treated pain interference had higher odds of incident cognitive impairment than those reporting no pain or pain interference (untreated adjusted odds ratio [aOR]: 2.18; 95% confidence interval [CI]: 1.09-4.36; treated aOR: 1.99; 95% CI: 1.15-3.44). Depressive symptoms explained 15.0% of the total effect of untreated pain and 25.3% of treated pain.
conclusionsAmong very old Mexican American adults, both treated and untreated pain interference was associated with incident cognitive impairment. This association was partially mediated by depressive symptoms, underscoring a need for depression screening in patients with chronic pain. Future work is needed to examine mechanistic/causal pathways between pain and subsequent cognitive impairment and the role of pharmacological and non-pharmacological treatments in these pathways.
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