Evidence map›Paper›PMID 37794731›Full record

ArticleJournal of anatomy2024

The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development.

Emily J Lodge, William B Barrell, Karen J Liu, Cynthia L Andoniadou

Open access · hybridAbstract read
In one paragraph

Article in Journal of anatomy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Emily J LodgeCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.ORCID 0000-0003-0932-8515
William B BarrellCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.ORCID 0000-0002-2810-2274
Karen J LiuCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.ORCID 0000-0002-2483-2165
Cynthia L AndoniadouCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.ORCID 0000-0003-4311-5855
King's College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/X512047/1Medical Research Council MC/PC21044Medical Research Council MC_PC_21044Medical Research Council MC_PC_21047Medical Research Council MR/T012153/1
6 · The paper itself

Abstract

The primary cilium is an essential organelle that is important for normal cell signalling during development and homeostasis but its role in pituitary development has not been reported. The primary cilium facilitates signal transduction for multiple pathways, the best-characterised being the SHH pathway, which is known to be necessary for correct pituitary gland development. FUZ is a planar cell polarity (PCP) effector that is essential for normal ciliogenesis, where the primary cilia of Fuz

Indexed as

Cell PolarityCiliaAnimalsCytoskeletal ProteinsHedgehog ProteinsIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutPituitary GlandProteinsCytoskeletal ProteinsFuz protein, mouseHedgehog ProteinsIntracellular Signaling Peptides and ProteinsProteinsFUZpituitary developmentprimary ciliumSHH signalling

Identifiers

PMID37794731
PMCPMC10780146
OpenAlexW4387379567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.