Evidence map›Paper›PMID 37794530›Full record

ArticleObesity (Silver Spring, Md.)2023

Children at high familial risk for obesity show executive functioning deficits prior to development of excess weight status.

Alaina L Pearce, Kyle Hallisky, Barbara J Rolls, Stephen J Wilson, Emma Rose, Charles F Geier, Hugh Garavan, Kathleen L Keller

Open access · hybridAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alaina L PearceDepartment of Nutritional Science, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-3157-6566
Kyle HalliskyDepartment of Nutritional Science, Pennsylvania State University, University Park, Pennsylvania, USA.
Barbara J RollsDepartment of Nutritional Science, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2374-1517
Stephen J WilsonDepartment of Psychology, Pennsylvania State University, University Park, Pennsylvania, USA.
Emma RoseEdna Bennett Pierce Prevention Research Center, Pennsylvania State University, University Park, Pennsylvania, USA.
Charles F GeierHuman Development and Family Studies, Pennsylvania State University, University Park, Pennsylvania, USA.
Hugh GaravanDepartment of Psychological Sciences, University of Vermont, Burlington, Vermont, USA.
Kathleen L KellerDepartment of Nutritional Science, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0001-6481-7018
Pennsylvania State University · USUniversity of Vermont · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Penn State Institutional Career Development CoreKL2TR002015 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2016 to 2025
$7.8M
Brain Mechanisms of Overeating in ChildrenR01DK110060 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI KELLER, KATHLEEN L · 2017 to 2021
$2.4M
Determining protective cognitive and eating behavior phenotypes for pediatric obesityF32DK122669 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PEARCE, ALAINA LUNDBERG · 2019 to 2021
$168k
NCATS NIH HHS KL2 TR002015NCATS NIH HHS TR000127NCATS NIH HHS TR002014NCATS NIH HHS TR002015NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NIDDK NIH HHS DK110060NIDDK NIH HHS DK122669-01NIDDK NIH HHS F32 DK122669NIDDK NIH HHS R01 DK110060
6 · The paper itself

Abstract

objectiveThe objective of this study was to determine whether children with healthy weight who vary by familial risk for obesity differ in executive functioning.

methodsChildren (age 7-8 years) without obesity (n = 93, 52% male) who differed by familial risk for obesity (based on maternal weight status) completed go/no-go and stop-signal tasks to assess inhibitory control and an N-back task to assess working memory. Dual energy x-ray absorptiometry measured adiposity. Linear and mixed-effect models assessed unique effects and relative importance analysis-quantified relative effects of familial risk and percent body fat.

resultsChildren at high compared with low familial risk showed worse inhibitory control; however, child adiposity was not associated with inhibitory control. Both high familial risk and greater child adiposity were associated with worse N-back performance when cognitive demand was high (2-back), but not low (0- and 1-back). The relative effect of familial risk on executive functioning was 2.7 to 16 times greater than the relative effect of percent body fat.

conclusionsThese findings provide initial evidence that deficits in executive functioning may precede the development of obesity in children at high familial risk for this disease. Additional family risk studies are needed to elucidate the pathways through which maternal obesity influences child executive functioning and risk for obesity.

Indexed as

Pediatric ObesityAdiposityChildExecutive FunctionFemaleGenetic Predisposition to DiseaseHumansMalePregnancyWeight Gain

Identifiers

PMID37794530
PMCPMC10884994
OpenAlexW4387357245

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.