Evidence map›Paper›PMID 37794521›Full record

ArticleDiabetology & metabolic syndrome2023

Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance.

Débora de Oliveira Fernandes, Fernanda Gracia César, Bruno Pereira Melo, Jéssica da Silva Faria Brandão, Kelvin Jaques Dos Santos, Marcelo Teixeira de Andrade, Marisa Cristina da Fonseca Casteluber, Moisés Vieira de Carvalho, Luiz Alexandre Medrado de Barcellos, Danusa Dias Soares and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Débora de Oliveira FernandesState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Fernanda Gracia CésarState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Bruno Pereira MeloExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Jéssica da Silva Faria BrandãoState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Kelvin Jaques Dos SantosState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Marcelo Teixeira de AndradeExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Marisa Cristina da Fonseca CasteluberState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Moisés Vieira de CarvalhoState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Luiz Alexandre Medrado de BarcellosState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil.
Danusa Dias SoaresExercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Juliana Bohnen GuimarãesState University of Minas Gerais - Ibirité Unit, Ibirité, Brazil. juliana.guimaraes@uemg.br.
Universidade do Estado de Minas Gerais · BRUniversidade Federal de Minas Gerais · BR

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais CBB - BIP-00346-17
6 · The paper itself

Abstract

Noni is a fruit with potential medicinal use preventing elevated blood glucose levels in diabetes mellitus. Its effects have been attributed to an antioxidant property in several other diseases. However, the effects of noni-chronic supplementation on exercise performance in the presence of diabetes conditions are not known. Thirty-two male Wistar rats were used to verify the effects of chronic noni (Morinda citrifolia L) juice administration on glycemia, triglyceride levels, and its relation to physical performance. In addition, it was verified if chronic noni supplementation is safe for clinical use through kidney morphology analysis. In half of the rats, diabetes mellitus (DM) was induced with STZ. All rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received a placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). Our dose was based on in previous study by Nayak et al. (2011) that observed a significant reduction in glycemia with 2 ml/kg of the noni juice without any toxicity effect cited. Groups were then given a third IWT to verify the effect of the noni juice on exercise performance (exercise time to fatigue, workload, maximal oxygen consumption) and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. The DM induction with STZ impaired the performance by 39%. Noni administration improved the time to fatigue and workload in DM rats beyond reducing hyperglycemia. These results could be associated with an improved energy efficiency promoted by noni ingestion, since the oxygen consumption was not different between the groups, although the exercise was longer in animals with noni ingestion. Our results provided evidence that chronic noni administration causes kidney damage since increased Bowman's space area in the control rats, suggesting glomerular hyperfiltration at the same magnitude as the non-treated DM group.In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.

Indexed as

Exercise, fatigue, glucoseOxygen consumptionRenal toxicity

Identifiers

PMID37794521
PMCPMC10548663
OpenAlexW4387337490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.