ArticleBMC cardiovascular disorders2023
Prognostic value of fibrosis-5 index combined with C-reactive protein in patients with acute decompensated heart failure.
Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Prognostic impacts of fibrosis-5 index in patients with chronic heart failure.Heart and vessels · 2026Article
- The prognostic significance of the fibrosis-5 index in patients with acute decompensated heart failure.Journal of geriatric cardiology : JGC · 2025Article
- Evaluating the prognostic significance of the modified prognostic nutritional index-C-reactive protein-to-albumin-to-lymphocyte index in acute decompensated heart failure: special attention to the impact of diabetes.Frontiers in nutrition · 2025Article
- Diagnosis of Multiple Organ Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: Vasoactive Inotropic Score, Renal Score, Fibrosis-5 Index and Lactate/Albumin Ratio.Diagnostics (Basel, Switzerland) · 2024Article
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7 authors.
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Abstract
backgroundFibrosis-5 (FIB-5) index is a marker of liver fibrosis and has been shown to have a good prognostic value for patients with acute heart failure (AHF), and C-reactive protein (CRP) has inflammatory properties and predicts adverse prognosis in patients with HF. However, the long-term prognostic value of FIB-5 index combined with CRP in patients with acute decompensated HF (ADHF) is yet unclear.
methodsThis retrospective study included 1153 patients with ADHF hospitalized from January 2018 to May 2022.The FIB-5 index was calculated as (albumin [g/L]×0.3 + PLT count [10
resultsDuring the mean follow-up period of 584 ± 12 days, 488 (42.3%) patients had MACCEs. Kaplan-Meier analysis revealed that the incidence of MACCEs was different in the four groups (P < 0.001). After adjusting for the confounding factors, the hazard ratio (HR) for MACCEs in Group 4 (low FIB-5 index + high CRP) was the highest (Model 1, HR = 2.04, 95%CI 1.58-2.65, P < 0.001; Model 2, HR = 1.67, 95%CI 1.28-2.18, P < 0.001; Model 3, HR = 1.66, 95%CI: 1.27-2.17, P < 0.001). Additionally, the combination of FIB-5 index and CRP enabled more accurate prediction of MACCEs than FIB-5 index alone (NRI, 0.314,95%CI 0.199-0.429; P < 0.001; IDI, 0.023; 95% CI 0.015-0.032; P < 0.001).
conclusionsIn patients with ADHF, the combination of the FIB-5 index and CRP may be useful in risk stratification in the future.
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