Evidence map›Paper›PMID 37794324›Full record

ArticleBMC neurology2023

Neurological disorders associated with COVID-19 in Sri Lanka.

Thashi Chang, Ruwani Wijeyekoon, Ajantha Keshavaraj, Udaya Ranawaka, Sunethra Senanayake, Pyara Ratnayake, Bimsara Senanayake, Manjula C Caldera, Gamini Pathirana, Darshana Sirisena and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Thashi ChangDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. thashichang@gmail.com.
Ruwani WijeyekoonAssociation of Sri Lankan Neurologists, Wijerama Mawatha, Colombo, Sri Lanka.
Ajantha KeshavarajTeaching Hospital Jaffna, Jaffna, Sri Lanka.
Udaya RanawakaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Sunethra SenanayakeNational Hospital of Sri Lanka, Colombo, Sri Lanka.
Pyara RatnayakeLady Ridgeway Hospital for Children, Colombo, Sri Lanka.
Bimsara SenanayakeNational Hospital of Sri Lanka, Colombo, Sri Lanka.
Manjula C CalderaTeaching Hospital Anuradhapura, Anuradhapura, Sri Lanka.
Gamini PathiranaNational Hospital of Sri Lanka, Colombo, Sri Lanka.
Darshana SirisenaColombo North Teaching Hospital, Ragama, Sri Lanka.
Jithangi WanigasingheDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Saman GunatilakeDepartment of Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
ASN COVID-19 Study Group
University of Sri Jayewardenepura · LKUniversity of Colombo · LKNational Hospital of Sri Lanka · LKColombo North Teaching Hospital · LKUniversity of Kelaniya · LKJaffna Teaching Hospital · LKLady Ridgeway Hospital for Children · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka.

methodsCOVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 - May 2022. Data was collected using a structured data form that was electronically transmitted to a central repository. All patients were evaluated and managed by a neurologist. Data were analysed using simple descriptive analysis to characterise demographic and disease related variables, and simple comparisons and logistic regression were performed to analyse outcomes and their associations.

resultsOne hundred and eighty-four patients with neurological manifestations associated with COVID-19 were recruited from all nine provinces in Sri Lanka. Ischaemic stroke (31%) was the commonest neurological manifestation followed by encephalopathy (13.6%), Guillain-Barre syndrome (GBS) (9.2%) and encephalitis (7.6%). Ischaemic stroke, encephalitis and encephalopathy presented within 6 days of onset of COVID-19 symptoms, whereas GBS and myelitis presented up to 10 days post onset while epilepsy and Bell palsy presented up to 20 - 40 days post onset. Haemorrhagic stroke presented either just prior to or at onset, or 10 - 25 days post onset of COVID-19 symptomatic infection. An increased frequency of children presenting with encephalitis and encephalopathy was observed during the Omicron variant predominant period. A poor outcome (no recovery or death) was associated with supplemental oxygen requirement during admission (Odds Ratio: 12.94; p = 0.046).

conclusionsThe spectrum and frequencies of COVID-19 associated neurological disorders in Sri Lanka were similar to that reported from other countries, with strokes and encephalopathy being the commonest. Requiring supplemental oxygen during hospitalisation was associated with a poor outcome.

Indexed as

Brain IschemiaCOVID-19EncephalitisGuillain-Barre SyndromeIschemic StrokeNervous System DiseasesStrokeChildHumansOxygenSARS-CoV-2Sri LankaOxygenCOVID-19NeurologySARS-CoV-2Sri Lanka

Identifiers

PMID37794324
PMCPMC10548601
OpenAlexW4387337371

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.