Trial reportInternational journal of obesity (2005)2024
Non-nutritive sweetened beverages versus water after a 52-week weight management programme: a randomised controlled trial.
Trial report in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02591134 (SWITCH), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SWITCH: EffectS of Non-nutritive sWeetened Beverages on appetITe During aCtive weigHt Loss
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials.Scientific reports · 2025Pooled it
- Artificially sweetened beverages do not influence metabolic risk factors: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Artificial and Other Non-Nutritive Sweeteners, the Microbiome, and Cardiometabolic Health.Current atherosclerosis reports · 2026Review
- Review
- Review
- Soda Sugar Supertaxes Pave the Way for a Large Increase in Consumption of Sweeteners and Its Long-Term Effects.Obesity (Silver Spring, Md.) · 2026Article
- Non-nutritive sweeteners and body weight in children with type 1 and type 2 diabetes: a critical narrative review of current evidence, methodological challenges, biological mechanisms, and clinical implications.Frontiers in nutrition · 2026Review
- Low- or No-Energy Sweeteners and Body Weight Management: Dissecting a "Minor" Effect.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Water intake, hydration, and weight management: the glass is half-full!Physiology & behavior · 2025Review
- Beverage consumption among adults in Newfoundland and Labrador, Canada prior to the implementation of a sugar-sweetened beverage tax.BMC public health · 2025Article
- Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners.Nutrients · 2025Review
- Declining trends in sweetness of the diet in the United Kingdom: 2008/9-2018/19.Frontiers in nutrition · 2025Article
- Educational Intervention Boosts Dietitians' Knowledge of the Safety and Approval of Low- and No-Calorie Sweeteners.Nutrients · 2024Article
- An Overview of Reviews on the Association of Low Calorie Sweetener Consumption With Body Weight and Adiposity.Advances in nutrition (Bethesda, Md.) · 2024Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveSugar-sweetened beverages are a substantial source of dietary sugar that can contribute to weight gain and the risk of type 2 diabetes. Dietary guidelines recommend non-nutritive sweetened (NNS) beverages to reduce sugar consumption, however, there is a need for long-term randomised controlled trials on their use. We aimed to compare the effects of NNS beverages and water on body weight during weight loss and maintenance in a behavioural weight management programme.
methodsIn this parallel-group, open-label, controlled equivalence trial, adults with a BMI of 27-35 kg/m
resultsOf 493 participants randomised (water: n = 246; NNS beverages: n = 247), 24.1% were NNS-naïve. At week 52, water and NNS beverages were non-equivalent, with significantly greater weight loss in the NNS beverages group. Participants consuming water maintained a weight loss of 6.1 kg over 52 weeks versus 7.5 kg with NNS beverages (difference [90% CI]: 1.4 kg [-2.6, -0.2]; p < 0.05).
conclusionsDuring a 52-week behavioural weight management programme, water and NNS beverages were non-equivalent, with weight loss maintained to a statistically greater extent with NNS beverages compared with water. However, this difference was not clinically significant. CLINICAL
trial registrationThis trial is registered with ClinicalTrials.gov: NCT02591134.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.