ReviewNature reviews. Gastroenterology & hepatology2024
Reduction in colorectal cancer incidence by screening endoscopy.
Review in Nature reviews. Gastroenterology & hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06342440 (A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Diagnostic sensitivity and specificity of enhanced computed tomography in colorectal tumors: a meta-analysis and systematic review.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Pooled it
- Single-round performance of colorectal cancer screening programs: a network meta-analysis of randomized clinical trials.BMC medicine · 2025Pooled it
- The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials.European journal of epidemiology · 2024Pooled it
- Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis.Military Medical Research · 2025Trial
- Evaluation efficacy and accuracy of a real-time computer-aided polyp detection system during colonoscopy: a prospective, multicentric, randomized, parallel-controlled study trial.Surgical endoscopy · 2025Trial
- Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management.MedComm · 2026Review
- Nonlinear association between number of lymph nodes resected and survival in T1N0M0 colorectal cancer: a SEER-based analysis.Updates in surgery · 2026Article
- Neighborhood-Level Food Insecurity and Colorectal Cancer Incidence in Texas: A Spatial Ecological Analysis.Research square · 2026Article
- Survival Outcomes of Patients With Colorectal Cancer After Primary Surgery: A Population-Based Study in Hainan, China.Cancer medicine · 2026Article
- Causal relationships between gut microbiota, C-reactive protein levels and colorectal cancer: A Mendelian randomization study.Medicine · 2026Article
- AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Early-detection and prevention effects of screening sigmoidoscopy: evidence from randomized trials revisited.Journal of the National Cancer Institute · 2026Article
- The association between residential natural vegetation exposure at diagnosis and colorectal cancer-specific mortality among colorectal cancer cases in Kentucky.Environmental research · 2026Article
- Comprehensive Landscape of Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer: From Genomics to Multi-Omics Integration in Precision Medicine.Journal of personalized medicine · 2026Review
- Global burden of early-onset colorectal cancer related to alcohol, tobacco, and physical inactivity: evidence from the global burden of disease 2021.Frontiers in oncology · 2026Article
- The impact of artificial intelligence on the adenoma detection rate : Comparison between experienced, intermediate and trainee endoscopists' adenoma detection rate.Wiener klinische Wochenschrift · 2026Article
- Contrasts in colorectal cancer incidence and mortality in screening trials of sigmoidoscopy vs the Nordic-European Initiative on Colorectal Cancer colonoscopy trial.Journal of the National Cancer Institute · 2025Article
- Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- The impact of adherence on colorectal cancer screening cost-effectiveness: A modeling study.PLoS medicine · 2025Article
- Overcoming prevalence bias in colorectal cancer screening studies by sensible analyses rather than ignoring it or giving up relevant effect measures.European journal of epidemiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) incidence rates decreased by up to 50% in older age groups in the USA in the era of the widespread uptake of screening colonoscopy, despite adverse trends in CRC risk factors and increasing CRC incidence at younger ages. However, reported first results from a randomized trial, the NordICC study, suggested rather modest effects of screening colonoscopy. As outlined in this Perspective, the apparent discrepancy between real-world and trial evidence could be explained by strong attenuation of effect estimates from screening endoscopy trials by several factors, including limited screening adherence, widespread uptake of colonoscopy outside the screening offers and the inclusion of prevalent, non-preventable CRC cases in reported numbers of incident cases. Alternative interpretations of screening endoscopy trial results accounting for prevalence bias are in line with trends in CRC incidence reduction in countries offering CRC screening, and should encourage more widespread implementation and uptake of effective CRC screening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.