ArticleNature2023
An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 65 citations in OpenAlex.
- Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients.Renal failure · 2026Article
- HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma.Signal transduction and targeted therapy · 2026Article
- 3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models.Nature communications · 2026Article
- Research Progress on Hemoglobin Expression in Non-Erythroid Cells and Tumor Cells.Journal of cellular physiology · 2026Review
- Characterization of erythroblastic island and tissue macrophages using a novel CD169-tdTomato-Cre mouse model and scRNA-seq.Blood red cells & iron · 2026Article
- Engineered Cyanobacteria-Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Piezo1 accelerates osteoarthritis progression via promotion of HBB-dependent oxidative phosphorylation.The Journal of biological chemistry · 2026Article
- ARHGAP36 imposes a bifurcate activation of adherens junction and actomyosin to promote entosis.Cell death and differentiation · 2026Article
- The Versatile Role of GDF5 in Chondrogenic Progenitor Cell-mediated Cartilage Regeneration via a Hyaluronic Acid-fibrin IPN Hydrogel Platform.Pharmaceutical research · 2026Article
- Chondrocytes in fracture healing: A review of chondrocyte journey.Chinese medical journal · 2026Review
- When broken bones need air: Erythrocytes step in to heal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Role of Hemoglobin in Temporomandibular Joint Osteoarthritis and the Therapeutic Potential of Hydroxyurea.International journal of dentistry · 2026Article
- Hyperuricemia was associated with metabolic response against brain injury instead of metabolism syndrome in Tibet: a cross-sectional analysis.Frontiers in endocrinology · 2026Article
- LOXL1, THY1, and TYMS define an annotation-derived hemoglobin-associated immunotranscriptomic signature in osteoarthritis cartilage.Frontiers in immunology · 2026Article
- Lactylation omics of rabbit rotator cuff tear reveals differentially modified proteins and metabolic relating therapy targets.Frontiers in medicine · 2026Article
- H3K56 lactylation promotes collagen II synthesis to modulate chondrocyte metabolism in posttraumatic osteoarthritis.Burns & trauma · 2026Article
- Insights Into the HIF-1α-Mediated NLRP3 Pyroptosis Pathway in the Regulation of Musculoskeletal Diseases in the High-Altitude Environment.Journal of inflammation research · 2026Review
- Bioinspired and smart material systems for auricular cartilage engineering: toward microenvironment-responsive and self-regulating scaffolds.Regenerative biomaterials · 2026Review
- Single-cell profiling reveals a shared proinflammatory macrophage signature across multiple organs in myopia.Cell discovery · 2025Article
- Glycolytic reprogramming impairs chondrocyte function in broilers with femoral head necrosis.The veterinary quarterly · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 5 institutions in 2 countries.
Feng Zhang *Department of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China. zhf1975@fmmu.edu.cn.ORCID 0000-0003-2034-5324
Bo Zhang *Frontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Academy of Military Medical Science; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.
Yuying WangDepartment of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China.
Runmin JiangDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Jin LiuDepartment of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China.
Yuexian WeiFrontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Academy of Military Medical Science; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.
Xinyue GaoFrontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Academy of Military Medical Science; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.
Yichao ZhuFrontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Academy of Military Medical Science; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.
Xinli WangDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Mao SunDepartment of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Junjun KangDepartment of Neurobiology, The Fourth Military Medical University, Xi'an, China.
Yingying LiuDepartment of Neurobiology, The Fourth Military Medical University, Xi'an, China.
Guoxing YouInstitute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Ding WeiDepartment of Cell Biology, National Translational Science Center for Molecular Medicine, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China.
Jiajia XinDepartment of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Junxiang BaoDepartment of Aerospace Hygiene, The Fourth Military Medical University, Xi'an, China.
Meiqing WangDepartment of Oral Anatomy and Physiology, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Yu GuDepartment of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China.
Zhe WangDepartment of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China.
Jing YeDepartment of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China.
Shuangping GuoDepartment of Pathology, School of Basic Medicine and Xijing Hospital, State Key Laboratory of Cancer Biology, Air Force Medical Center, The Fourth Military Medical University, Xi'an, China.
Hongyan HuangDepartment of Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing, China.ORCID 0000-0001-8340-6660
Qiang SunFrontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Academy of Military Medical Science; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China. sunq@bmi.ac.cn.ORCID 0000-0002-5342-0637
Xijing Hospital · CNAir Force Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNCapital Medical University · CNAcademy of Military Medical Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport oxygen over a long range, its physiological roles outside erythrocytes are largely elusive
Indexed as
Adaptation, PhysiologicalCell HypoxiaChondrocytesHemoglobinsCartilage, ArticularCell DeathCytoplasmEosine Yellowish-(YS)ErythrocytesGlycolysisHumansKruppel-Like Transcription FactorsOxygenEosine Yellowish-(YS)erythroid Kruppel-like factorHemoglobinsKruppel-Like Transcription FactorsOxygen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.