Evidence map›Paper›PMID 37794188›Full record

ArticleNature2023

Large-scale plasma proteomics comparisons through genetics and disease associations.

Grimur Hjorleifsson Eldjarn, Egil Ferkingstad, Sigrun H Lund, Hannes Helgason, Olafur Th Magnusson, Kristbjorg Gunnarsdottir, Thorunn A Olafsdottir, Bjarni V Halldorsson, Pall I Olason, Florian Zink and 23 more

Erratum issuedOpen access · hybridAbstract readComparative Study
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 364 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
364citing papers in PubMed, 5 pooled it
139.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

364 citing papers in PubMed, 5 syntheses or guidelines pooled it, 444 citations in OpenAlex.

  1. Pooled it
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  6. Article
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  10. Review
  11. Explainable Plasma Proteomics-Based Machine Learning for Osteoporosis Diagnosis, Prognosis, and Protein Biomarker Discovery in the UK Biobank.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  12. Article
  13. Article
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  15. Systemic Proteome Profiling to Differentiate Primary Glomerular Diseases.Journal of the American Society of Nephrology : JASN · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

304 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 2 institutions in 1 country.

Grimur Hjorleifsson Eldjarn *deCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-9580-6685
Egil Ferkingstad *deCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-8090-7988
Sigrun H LunddeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-3806-2296
Hannes HelgasondeCODE Genetics/Amgen, Reykjavik, Iceland.
Olafur Th MagnussondeCODE Genetics/Amgen, Reykjavik, Iceland.
Kristbjorg GunnarsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Thorunn A OlafsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-5454-938X
Bjarni V HalldorssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0003-0756-0767
Pall I OlasondeCODE Genetics/Amgen, Reykjavik, Iceland.
Florian ZinkdeCODE Genetics/Amgen, Reykjavik, Iceland.
Sigurjon A GudjonssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Gardar SveinbjornssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0003-2429-9468
Magnus I MagnussondeCODE Genetics/Amgen, Reykjavik, Iceland.
Agnar HelgasondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-8545-3767
Asmundur OddssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-4606-5163
Gisli H HalldorssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-7067-9862
Magnus K MagnussondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-8593-4934
Saedis SaevarsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-9392-6184
Thjodbjorg EiriksdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0003-1009-7398
Gisli MassondeCODE Genetics/Amgen, Reykjavik, Iceland.
Hreinn StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Ingileif JonsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-8339-150X
Hilma HolmdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-9517-6636
Thorunn RafnardeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0003-0491-7046
Pall MelsteddeCODE Genetics/Amgen, Reykjavik, Iceland.
Jona SaemundsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Gudmundur L NorddahldeCODE Genetics/Amgen, Reykjavik, Iceland.
Gudmar ThorleifssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0003-4623-9087
Magnus O UlfarssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Daniel F GudbjartssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-5222-9857
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Patrick SulemdeCODE Genetics/Amgen, Reykjavik, Iceland. patrick.sulem@decode.is.ORCID 0000-0001-7123-6123
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland. kstefans@decode.is.ORCID 0000-0003-1676-864X
deCODE Genetics (Iceland) · ISReykjavík University · IS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge the gap between the genome and diseases. Here we performed association studies of Olink Explore 3072 data generated by the UK Biobank Pharma Proteomics Project

Indexed as

Blood ProteinsDisease SusceptibilityGenomicsGenotypePhenotypeProteomicsAfricaAsia, SouthernBiological Specimen BanksDatasets as TopicGenome, HumanHumansIcelandIrelandPlasmaProteomeBlood ProteinsProteome

Identifiers

PMID37794188
PMCPMC10567571
OpenAlexW4387344358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.