Evidence map›Paper›PMID 37794139›Full record

Trial reportClinical oral investigations2023

Alveolar cleft reconstruction using bone marrow aspirate concentrate and iliac cancellous bone: A 12-month randomized clinical study.

Alshaimaa Ahmed Shabaan, Ahmad Salahuddin, Inass Aboulmagd, Reham Ragab, Khaled Amr Salah, Adel Rashid, Haytham Mohamed Ayad, Walaa Abd El Aty Ahmed, Shaimaa Mohsen Refahee

3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04414423 nacompletednot on this map

Combination of Bone Marrow Concentrate and Iliac Cancellous Bone Graft in Alveolar Cleft Grafting: a Clinical & Radiographic Evaluation

TypeinterventionalSponsorFayoum UniversityRan2020 to 2021Enrolled18ConditionsAlveolar Cleft GraftingArmsbone marrow concentrate alveolar cleft grafting, Autogenous alveolar grafting
NCT07045246 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Evaluation of the Effect of Co-enzyme Q10 on the Bone Volume of Alveolar Cleft Reconstruction (Randomized Clinical Trial)

TypeinterventionalSponsorFayoum UniversityRan2025 to 2026Enrolled12ConditionsCoenzyme Q10, Alveolar Cleft GraftingArmsCoenzyme Q 10, iliac bone graft
NCT07786259 nacompletednot on this mapstarted 2025, after this paper: background citation

Evaluation of Bone Marrow Aspirate Concentrate Combined With Bovine Bone Graft for Unilateral Alveolar Cleft Repair (A Randomized Controlled Clinical Trial)

TypeinterventionalSponsorTanta UniversityRan2025 to 2026Enrolled16ConditionsUnilateral Alveolar Cleft of MaxillaArmsBMAC-Enriched Bovine Bone Grafting, Bovine Bone Grafting
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Cellular therapies for bone repair: current insights.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Alshaimaa Ahmed ShabaanOral & Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.ORCID https://orcid.org/0000-0002-6105-4999
Ahmad SalahuddinBiochemistry Department, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.ORCID https://orcid.org/0000-0002-7382-4284
Inass AboulmagdOral & Maxillofacial Radiology, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.ORCID https://orcid.org/0000-0003-0737-1384
Reham RagabBiomedical Informatics and Medical Statistics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.ORCID https://orcid.org/0000-0003-3127-8219
Khaled Amr SalahOral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, 11111, Egypt.ORCID https://orcid.org/0000-0003-3484-3789
Adel RashidOrthodontics, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.ORCID https://orcid.org/0000-0003-3849-183X
Haytham Mohamed AyadOral & Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.ORCID https://orcid.org/0000-0003-3189-7714
Walaa Abd El Aty AhmedOral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University, Cairo, 11111, Egypt.ORCID https://orcid.org/0000-0001-5346-5475
Shaimaa Mohsen RefaheeOral & Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt. smr11@fayoum.edu.eg.ORCID https://orcid.org/0000-0002-7550-1913
Fayoum University · EGCairo University · EGAlexandria University · EGDamanhour University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to compare the bone density and volume in patients with alveolar cleft reconstructions utilizing bone marrow aspirate concentrate with iliac graft versus iliac graft alone. MATERIAL AND

methodsThirty-six patients with unilateral alveolar cleft were randomly allocated into either an intervention group receiving an iliac bone graft mixed with bone marrow concentrate or a control group receiving an iliac bone graft. Cone beam CT was obtained preoperative, 6 and 12 months postoperatively to assess the bone density of the graft and bone volume of the alveolar defect, and then, the bone loss ratio was calculated.

resultsBone volume and bone density demonstrated a statistically significant increase in the intervention group at 6 and 12 months. In contrast, the bone loss ratio decreased significantly in the intervention group throughout the follow-up period.

conclusionA combination of bone marrow concentrate and iliac cancellous bone in alveolar cleft reconstruction may improve bone densities and volume in addition to decreasing graft loss rate. CLINICAL SIGNIFICANCE: Using of bone marrow aspirate concentrate will decrease the amount of the graft needed and decrease the ratio of bone loss at the grafted site by the time. Trial registration ClinicalTrials.org ( NCT04414423 ) 4/6/2020.

Indexed as

Alveolar Bone GraftingCleft LipCleft PalateBone MarrowBone TransplantationCancellous BoneHumansIliumAlveolar bone graftingBone graftingBone marrowBone marrow cellsGrowth factors

Identifiers

PMID37794139
PMCPMC10630224
OpenAlexW4387345839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.