SynthesisNature communications2023
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
35.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa.The British journal of dermatology · 2025Pooled it
- Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis.Nature communications · 2025Pooled it
- Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization.Acta dermato-venereologica · 2025Pooled it
- Gene variants associated with skin barrier dysfunction in atopic dermatitis: a systematic review and meta-analysis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Pooled it
- Clinical and Molecular Effect of the Anti-IL-18 Antibody Aletekitug in Adults With Atopic Dermatitis.Allergy · 2026Trial
- Article
- Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis.Allergy · 2026Review
- Atopic dermatitis.Nature reviews. Disease primers · 2026Review
- Article
- Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation.PLoS genetics · 2026Article
- Maternal-prenatal gut microbiome-systemic metabolome perturbations and TGenome medicine · 2026Article
- Prediction of allergic disease trajectories from birth up to adolescence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026Article
- Genetic polymorphisms of SPP1 and MGP are associated with thumb osteoarthritis: a replication study in the Chinese population.Molecular biology reports · 2026Article
- Integrative mendelian randomization approaches for therapeutic target prioritisation in immune-mediated diseases.Scientific reports · 2026Article
- Single-CellInternational journal of molecular sciences · 2026Article
- Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.Nature communications · 2026Article
- The Role of the Cysteamine Dioxygenase (ADO) Gene in Atopic Dermatitis.Acta dermato-venereologica · 2026Article
- Uncovering pleiotropic loci linking keratoconus and allergic diseases through integrative genomic analyses.Scientific reports · 2026Article
- Exploring the relative contribution of genetic and external exposomic risk scores to allergies in elderly women.Scientific reports · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
134 authors at 20 institutions in 16 countries.
Ashley Budu-Aggrey *Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England.ORCID http://orcid.org/0000-0002-8911-2492
Anna Kilanowski *Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-5328-6274
Maria K SobczykMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England.ORCID http://orcid.org/0000-0003-0000-4100
23andMe Research Team
Suyash S Shringarpure23andMe, Inc., Sunnyvale, CA, USA.ORCID http://orcid.org/0000-0001-6464-2668
Ruth MitchellMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England.ORCID http://orcid.org/0000-0002-3506-160X
Kadri ReisEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-2144-5856
Anu ReigoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Estonian Biobank Research Team
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-2964-6011
Mari NelisEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Nao TanakaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-2085-4682
Ben M BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.ORCID http://orcid.org/0000-0002-3058-1059
Laurent F ThomasK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.ORCID http://orcid.org/0000-0003-0548-2486
Pol Sole-NavaisDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-3326-266X
Christopher FlatleyDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Antonio Espuela-OrtizGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.ORCID http://orcid.org/0000-0003-0572-9549
Esther Herrera-LuisGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.ORCID http://orcid.org/0000-0003-4150-5454
Jesus V T LomincharNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.
Ingo MarenholzMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Aleix Arnau-SolerMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0001-9768-0513
Ayoung JeongSwiss Tropical and Public Health Institute, CH-4123, Basel, Switzerland.ORCID http://orcid.org/0000-0003-1542-0756
Katherine A FawcettDepartment of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.ORCID http://orcid.org/0000-0002-6675-2112
Hansjorg BaurechtDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Elke RodriguezDepartment of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0003-3692-3950
Alexessander Couto AlvesSchool of Biosciences and Medicine, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0001-8519-7356
Ashish KumarDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Solna, Sweden.
Patrick M SleimanCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Xiao ChangCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Carolina Medina-GomezThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7999-5538
Chen HuThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Cheng-Jian XuUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1586-4672
Cancan QiUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, The Netherlands.
Sarah El-HeisMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Philip TitcombeMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Elie AntounFaculty of Medicine, University of Southampton, Southampton, UK.
João FadistaDepartment of Bioinformatics & Data Mining, Måløv, Denmark.
Carol A WangSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID http://orcid.org/0000-0002-4301-3974
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Baojun WuCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Medicine, Henry Ford Health, Detroit, MI, 48104, USA.
Sara KressEnvironmental Epidemiology of Lung, Brain and Skin Aging, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-8007-5357
Dilini M KothalawalaHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Latha KadalayilHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Jiasong DuanDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3557-0364
Sabelo HadebeDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Thomas HoffmannInstitute for Human Genetics, UCSF, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0001-6893-4449
Eric JorgensonRegeneron Genetics Center, Tarrytown, NY, USA.
Hélène ChoquetDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0001-9839-8667
Neil RischInstitute for Human Genetics, UCSF, San Francisco, CA, 94143, USA.
Pål NjølstadCenter for Diabetes Research, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo, 0450, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Stefan JohanssonCenter for Diabetes Research, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.ORCID http://orcid.org/0000-0002-2298-7008
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1045-1898
Tong GongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Vilhelmina UllemarDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8949-2587
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Agnieszka SzwajdaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Esteban G BurchardDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7475-2035
Jacob P ThyssenDepartment of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Line L KårhusCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Thomas M DantoftCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Alexander C S N JeanrenaudMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Ahla GhauriMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0003-4665-3624
Andreas ArnoldClinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-6839-0605
Susanne LauDepartment of Pediatric Respiratory Medicine, Immunology, and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
Norbert HübnerMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0002-1218-6223
Medea ImbodenSwiss Tropical and Public Health Institute, CH-4123, Basel, Switzerland.
Alessia ViscontiDepartment of Twin Research & Genetics Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0003-4144-2019
Mario FalchiDepartment of Twin Research & Genetics Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0002-5646-1004
Veronique BatailleDepartment of Twin Research & Genetics Epidemiology, Kings College London, London, UK.
Pirro HysiDepartment of Twin Research & Genetics Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0001-5752-2510
Natalia BallardiniDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Solna, Sweden.
Dorret I BoomsmaDept Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Jouke J HottengaDept Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-5668-2368
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Tarunveer S AhluwaliaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7464-3354
Jakob StokholmCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4989-9769
Bo ChawesCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6846-6243
Ann-Marie M SchoosCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5827-0885
Ana EspluguesNursing School, University of Valencia, FISABIO-University Jaume I-University of Valencia, Valencia, Spain.
Mariona BustamanteISGlobal, Institute for Global Health, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0127-2860
Benjamin RabyChanning Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Syed ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Chris German23andMe, Inc., Sunnyvale, CA, USA.
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lili A MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Andres MetspaluEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3718-796X
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6452-4095
Katrina AbuabaraDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Mari LøsetK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.ORCID http://orcid.org/0000-0003-3736-6551
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.
Bo JacobssonDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-5079-2374
Maria Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.ORCID http://orcid.org/0000-0003-0332-437X
David P StrachanPopulation Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.ORCID http://orcid.org/0000-0001-7854-1366
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.ORCID http://orcid.org/0000-0001-5526-1070
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0002-0994-0184
Young-Ae LeeMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0002-1817-9163
Nicole Probst-HenschSwiss Tropical and Public Health Institute, CH-4123, Basel, Switzerland.
Stephan WeidingerDepartment of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0003-3944-252X
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health,Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2149-0630
Erik MelénDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-8248-0663
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0003-2814-7461
Alan D IrvineDepartment of Clinical Medicine, Trinity College, Dublin, Ireland.ORCID http://orcid.org/0000-0002-9048-2044
Deborah JarvisRespiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Tamar NijstenDepartment of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9940-2875
Liesbeth DuijtsDepartment of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-7531-4547
Gerard H KoppelmannUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8567-3252
Keith M GodfreyMRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID http://orcid.org/0000-0002-4643-0618
Sheila J BartonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1478-649X
Craig E PennellSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID http://orcid.org/0000-0002-0937-6165
Peter D SlyChildren's Health and Environment Program, Child Health Research Centre, The University of Queensland, South Brisbane, 4101, Queensland, Australia.ORCID http://orcid.org/0000-0001-6305-2201
Patrick G HoltTelethon Kids Institute, University of Western Australia, Perth, WA, Australia.ORCID http://orcid.org/0000-0003-1193-0935
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Medicine, Henry Ford Health, Detroit, MI, 48104, USA.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2003-1018
John CurtinDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, England.
Angela SimpsonDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, England.
Clare MurrayDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, England.ORCID http://orcid.org/0000-0002-8961-8055
Tamara SchikowskiEnvironmental Epidemiology of Lung, Brain and Skin Aging, Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Supinda BunyavanichDivision of Allergy and Immunology, Department of Pediatrics, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6108-439X
Scott T WeissChanning Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-9998-0464
Josine L MinMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England.ORCID http://orcid.org/0000-0003-4456-9824
Sara J BrownCentre for Genomics and Experimental Medicine, Institute for Genetics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, UK EH4 2XU, Scotland.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-5345-2049
Lavinia PaternosterMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England. l.paternoster@bristol.ac.uk.ORCID http://orcid.org/0000-0003-2514-0889
University of Copenhagen · DKKarolinska Institutet · SEUniversity of Tartu · EEMax Delbrück Center · DEErasmus MC · NLKing's College London · GBNorwegian University of Science and Technology · NOUniversity Medical Center Groningen · NLUniversity of Bristol · GBUniversity of California, San Francisco · USChildren's Hospital of Philadelphia · USHelmholtz Zentrum München · DEManchester Academic Health Science Centre · GBMRC Lifecourse Epidemiology Unit · GBSwiss Tropical and Public Health Institute · CHUniversidad de La Laguna · ESUniversity of Southampton · GB23andMe (United States) · USBrigham and Women's Hospital · USFrederiksberg Hospital · DK
Funding
The Integrative Genomics of Acute Asthma ControlR01HL118455 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLSTEIN, JOSHUA, RABY, BENJAMIN ALEXANDER · 2014 to 2024
$6.5MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00032/1Medical Research Council MR/J012165/1Medical Research Council MR/S019669/1NHLBI NIH HHS R01 HL118455Wellcome TrustWellcome Trust 220875/Z/20/Z
Abstract
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.
Indexed as
Dermatitis, AtopicGenome-Wide Association StudyBlack PeopleGenetic Predisposition to DiseaseHispanic or LatinoHumansPolymorphism, Single Nucleotide
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