Evidence map›Paper›PMID 37793645›Full record

ArticlePediatric obesity2024

Immune profile of adipose tissue from youth with obesity and asthma.

Anna Reichenbach, Wade O'Brien, Sarai Duran, Kayla J Authelet, Robert J Freishtat, Evan P Nadler, Deepa Rastogi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anna ReichenbachChildren's National Research Institute, Children's National Hospital, Washington, DC, USA.
Wade O'BrienChildren's National Research Institute, Children's National Hospital, Washington, DC, USA.
Sarai DuranChildren's National Research Institute, Children's National Hospital, Washington, DC, USA.
Kayla J AutheletGeorge Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Robert J FreishtatChildren's National Research Institute, Children's National Hospital, Washington, DC, USA.
Evan P NadlerChildren's National Research Institute, Children's National Hospital, Washington, DC, USA.
Deepa RastogiChildren's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-5714-9250
Children's National · USAlbert Einstein College of Medicine · USGeorge Washington University · US

Funding

Investigating the CDC42 pathway as a novel pathway for pediatric non-atopic obesity-related asthmaR01HL141849 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2019 to 2023
$2.4M
Crosstalk Between T Cells and Airway Smooth Muscle in Obesity-Related AsthmaR03HL144534 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2018 to 2019
$177k
NHLBI NIH HHS R01 HL141849NHLBI NIH HHS R03 HL144534NIH HHS HL141849
6 · The paper itself

Abstract

backgroundObesity is a risk factor for paediatric asthma. Obesity-mediated systemic inflammation correlates with metabolic dysregulation; both are associated with asthma burden. However, adipose tissue inflammation is not defined in obesity-related asthma.

objectiveDefine adipose tissue inflammation and its association with metabolic measures in paediatric obesity-related asthma.

methodsCellular profile of stromal vascular fraction from visceral adipose tissue (VAT) from youth with obesity-related asthma (n = 14) and obesity without asthma (n = 23) was analyzed using flow cytometry and correlated with metabolic measures.

resultsCompared to youth without asthma, VAT from youth with obesity-related asthma was enriched for leukocytes and macrophages, including M1 and dual M1M2 cells, but did not differ for CD4

conclusionsEnrichment of macrophage-mediated inflammation in VAT from youth with obesity-related asthma supports its role in systemic inflammation linked with asthma morbidity. Lack of correlation of VAT cells with metabolic dysregulation in youth with obesity-related asthma identifies a need to define distinguishing factors associated with VAT inflammation in obesity-related asthma.

Indexed as

AsthmaInsulin ResistanceAdipose TissueAdolescentChildEndothelial CellsHumansInflammationIntra-Abdominal FatObesityadipose tissueasthmachildrenimmune profileobesity

Identifiers

PMID37793645
PMCPMC12338038
OpenAlexW4387357028

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.