Evidence map›Paper›PMID 37793537›Full record

ArticleThe journal of pain2024

Hypernegative GABA

Haram R Kim, Manzhao Long, Gabriella Sekerková, Amadeus Maes, Ann Kennedy, Marco Martina

Open access · bronzeAbstract read
In one paragraph

Article in The journal of pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Bidirectional Regulation of GABALife (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Haram R KimDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Manzhao LongDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Gabriella SekerkováDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Amadeus MaesDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Ann KennedyDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Marco MartinaDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Northwestern University · US

Funding

Rodent Behavior CoreP50DA044121 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RADULOVIC, JELENA · 2018 to 2022
$9.0M
Modulation of the prefrontal cortical network in neuropathic painR01NS112292 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARTINA, MARCO · 2020 to 2024
$2.6M
Modeling a Neural Circuit for Flexible Control of Innate BehaviorsR00MH117264 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KENNEDY, ANN KATHRYN · 2021 to 2023
$742k
Modeling a neural circuit for flexible control of innate behaviorsK99MH117264 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KENNEDY, ANN KATHRYN · 2019 to 2020
$222k
NIDA NIH HHS P50 DA044121NIMH NIH HHS K99 MH117264NIMH NIH HHS R00 MH117264NINDS NIH HHS R01 NS112292
6 · The paper itself

Abstract

Deactivation of the medial prefrontal cortex (mPFC) has been broadly reported in both neuropathic pain models and human chronic pain patients. Several cellular mechanisms may contribute to the inhibition of mPFC activity, including enhanced GABAergic inhibition. The functional effect of GABA

Indexed as

Chronic PainNeuralgiaAnimalsChloridesgamma-Aminobutyric AcidHumansK Cl- CotransportersMicePrefrontal CortexProtein IsoformsPyramidal CellsSolute Carrier Family 12, Member 2Chloridesgamma-Aminobutyric AcidK Cl- CotransportersProtein IsoformsSolute Carrier Family 12, Member 2InhibitionK-Cl cotransporter isoform 2Na-K-2Cl cotransporter isoform 1neuropathic painperforated patch

Identifiers

PMID37793537
PMCPMC10841847
OpenAlexW4387248192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.