ArticleSleep2024
Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents.
Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Data-driven derivation of a multidimensional sleep health framework in adolescents.Sleep health · 2026Article
- Circadian misalignment and adolescent obesity risk behaviors: physical & sedentary activity, dietary intake, and food reward.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications.Frontiers in sleep · 2026Review
- Chronotype-specific associations of sleep-wake schedule with behavioral, physiological, and psychological parameters.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Association of sleep variability and irregularity with gestational metabolic syndrome: a birth cohort study.Frontiers in endocrinology · 2026Article
- Article
- Circadian rhythms in metabolism and mental health: a reciprocal regulatory network with implications for metabolic and neuropsychiatric disorders.Current opinion in physiology · 2025Review
- Association of body roundness index with circadian syndrome: a cross-sectional study using NHANES data from 2009 to 2018.Journal of health, population, and nutrition · 2025Article
- Article
- Article
- Investigating preschool-aged chronotype and social jetlag as predictors of early adolescent diet and BMI z-score: an eight-year follow-up from the DAGIS study.International journal of obesity (2005) · 2025Article
- Investigating preschool-aged chronotype and social jetlag as predictors of early adolescent diet and BMI z-score: an eight-year follow-up from the DAGIS study.International journal of obesity (2005) · 2025Article
- Weight-neutral approach and later sleep midpoint in adolescents with "emerging polycystic ovary syndrome phenotype" as vehicles for sustainable weight loss.F&S reports · 2024Article
- Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Gender and activity disparities in the relationship between circadian syndrome and gallstone disease.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesAlthough insufficient sleep is a risk factor for metabolic syndrome (MetS), the circadian timing of sleep (CTS) is also involved in cardiac and metabolic regulation. We examined whether delays and deviations in the sleep midpoint (SM), a measure of CTS, modify the association between visceral adipose tissue (VAT) and MetS in adolescents.
methodsWe evaluated 277 adolescents (median 16 years) who had at least 5 nights of at-home actigraphy (ACT), in-lab polysomnography (PSG), dual-energy X-ray absorptiometry (DXA) scan, and MetS score data. Sleep midpoint (SM), sleep irregularity (SI), and social jetlag (SJL) were examined as effect modifiers of the association between VAT and MetS, including waist circumference, blood pressure, insulin resistance, triglycerides, and cholesterol. Linear regression models adjusted for demographics, ACT-sleep duration, ACT-sleep variability, and PSG-apnea-hypopnea index.
resultsThe association between VAT and MetS was significantly stronger (p-values for interactions < 0.001) among adolescents with a schooldays SM later than 4:00 (2.66 [0.30] points increase in MetS score), a SI higher than 1 hour (2.49 [0.30]) or a SJL greater than 1.5 hours (2.15 [0.36]), than in those with an earlier SM (<3:00; 1.76 [0.28]), lower SI (<30 minutes; 0.98 [0.70]), or optimal SJL (<30 minutes; 1.08 [0.45]).
conclusionsA delayed sleep phase, an irregular sleep-wake cycle, and greater social jetlag on schooldays identified adolescents in whom VAT had a stronger association with MetS. Circadian misalignment is a risk factor that enhances the impact of visceral obesity on cardiometabolic morbidity and should be a target of preventative strategies in adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.