ArticleScience advances2023
SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- BDNF regulates pituitary stem cell engagement toward precursor state.Stem cell reports · 2026Article
- Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research.Cell reports · 2026Article
- Accessibility at a primed distal Fshb-Kcna4 super-enhancer is facilitated by Foxl2 during gonadotrope differentiation.Endocrinology · 2026Article
- BDNF Regulates Pituitary Stem Cell Engagement towards precursor state.bioRxiv : the preprint server for biology · 2026Article
- Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells.Nature communications · 2025Article
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice.Endocrinology · 2025Article
- Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape.iScience · 2025Article
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes.Frontiers in endocrinology · 2025Article
- Gene Misexpression in aJournal of the Endocrine Society · 2024Article
- Single-Cell RNA Sequencing and Its Applications in Pituitary Research.Neuroendocrinology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Stem cell (SC) differentiation and maintenance of resultant progeny underlie cell turnover in many organs, but it is difficult to pinpoint the contribution of either process. In the pituitary, a central regulator of endocrine axes, adult SCs undergo activation after target organ ablation, providing a well-characterized paradigm to study an adaptative response in a multi-organ system. Here, we used single-cell technologies to characterize SC heterogeneity and mobilization together with lineage tracing. We show that SC differentiation occurs more frequently than thought previously. In adaptative conditions, differentiation increases and is more diverse than demonstrated by the lineage tracing experiments. Detailed examination of SC progeny suggests that maintenance of selected nascent cells underlies SC output, highlighting a trophic role for the microenvironment. Analyses of cell trajectories further predict pathways and potential regulators. Our model provides a valuable system to study the influence of evolving states on the mechanisms of SC mobilization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.