ArticlePLoS neglected tropical diseases2023
Prevalence of malaria and dengue co-infections among febrile patients during dengue transmission season in Kassala, eastern Sudan.
Article in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Viral and host determinants of arboviral disease severity in African populations: A systematic review with meta-analysis.PLoS neglected tropical diseases · 2026Pooled it
- When dengue is not the answer: diagnostic anchoring bias in febrile illnesses in conflict-affected settings.Annals of medicine and surgery (2012) · 2026Article
- Assessing the Knowledge, Attitudes, and Practices (KAP) of Sudanese citizens regarding dengue fever prevention and control during the 2025 outbreak in Sudan: a multi-center cross-sectional study.BMC public health · 2026Article
- Hidden in Plain Sight: The Enduring Challenge of Neglected Tropical Diseases in Khartoum State, Sudan.Journal of tropical medicine · 2026Article
- Coinfection of Malaria and Dengue Fever in Patients With Acute Undifferentiated Febrile Illnesses in Ghana: A Narrative Review.BioMed research international · 2026Review
- The Relationship Between Malaria and Pain: A Mini-Review.The American journal of tropical medicine and hygiene · 2025Review
- Seroprevalence of dengue virus infection among febrile patients visiting healthcare facilities in the selected districts of Afar region, Northeast Ethiopia.BMC infectious diseases · 2025Article
- A comprehensive review on the epidemiology of arboviruses in the Eastern Mediterranean Region (EMRO): insights from the WHO's Regional Office.GMS hygiene and infection control · 2025Article
- Severe coinfection of dengue and malaria: A case report.Clinical case reports · 2024Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria and dengue are common mosquito-borne diseases around the world that cause high mortality and morbidity. The number of cases of both diseases is currently rising in Sudan and is associated with climate and environmental changes. Limited information is available on malaria and dengue co-infections and the severity of the two diseases among febrile patients in eastern Sudan. Thus, this study aimed to estimate the prevalence of malaria and dengue co-infections among febrile patients in Kassala, eastern Sudan. METHODOLOGY/PRINCIPAL
findingsA cross-sectional hospital-based study was conducted among febrile patients from September to December 2019. A total of 395 patients were enrolled after consenting to participate in the study. Demographic and clinical data were collected by structured questionnaires. Blood samples were provided to diagnose malaria infections using microscopy and polymerase chain reaction (PCR) and for serology diagnosis of dengue using enzyme-linked immune sorbent assay (ELISA) IgM. Multiple logistic regression analysis was used to assess the association between demographic information, clinical symptoms and malaria and dengue co-infections. Out of 395 febrile patients examined 158 (40%) were malaria positive and 67 (17%) were dengue positive. The prevalence of malaria and dengue co-infections was 6.6% (26/395). Results of multiple logistic regression indicated that elder patients (41-60 years) had less rate of co-infections (OR = 0.3, 95% CI 0.11 to 0.81, p-value = 0.018), while patients of co-infections were eight times more likely to have fatigue, and two times more likely to suffer from joint and muscle pain and this difference was statistically significant with (OR = 8.3, 95% CI: 1.89 to 37.22, p-value = 0.005) and (OR = 2.4, 95% CI 1.10 to 5.39, p-value = 0.027), respectively. CONCLUSIONS/SIGNIFICANCE: This study confirmed the existence of malaria and dengue co-infections among febrile patients in Kassala, eastern Sudan for the first time. The severity of clinical symptoms of patients with malaria and dengue co-infections was observed, and the co-infections were found prevalent among young people.
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