Evidence map›Paper›PMID 37792488›Full record

ArticleBiomacromolecules2023

Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.

Calise Bahou, Richard J Spears, Angela M Ramírez Rosales, Léa N C Rochet, Lydia J Barber, Ksenia S Stankevich, Juliana F Miranda, Tobias C Butcher, Adam M Kerrigan, Vlado K Lazarov and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Calise BahouDepartment of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.
Richard J SpearsDepartment of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.
Angela M Ramírez RosalesDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.ORCID 0000-0002-0318-8817
Léa N C RochetDepartment of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.ORCID 0009-0003-5594-6290
Lydia J BarberDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.
Ksenia S StankevichDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.
Juliana F MirandaYork Biomedical Research Institute, University of York, Heslington YO10 5DD, U.K.
Tobias C ButcherDepartment of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.
Adam M KerriganThe York JEOL Nanocentre, University of York, Heslington YO10 5BR, U.K.ORCID 0000-0001-8222-841X
Vlado K LazarovSchool of Physics, Engineering, and Technology, University of York, Heslington YO10 5DD, U.K.
William GreyYork Biomedical Research Institute, University of York, Heslington YO10 5DD, U.K.ORCID 0000-0001-8209-5645
Vijay ChudasamaDepartment of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.ORCID 0000-0002-8876-3285
Christopher D SpicerDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.ORCID 0000-0001-8787-578X
University of York · GBUniversity College London · GB

Funding

Medical Research Council MR/X007146/1Wellcome Trust 225257Wellcome Trust 225257/Z/22/Z
6 · The paper itself

Abstract

Thiol-reactive Michael acceptors are commonly used for the formation of chemically cross-linked hydrogels. In this paper, we address the drawbacks of many Michael acceptors by introducing pyridazinediones as new cross-linking agents. Through the use of pyridazinediones and their mono- or dibrominated analogues, we show that the mechanical strength, swelling ratio, and rate of gelation can all be controlled in a pH-sensitive manner. Moreover, we demonstrate that the degradation of pyridazinedione-gels can be induced by the addition of thiols, thus providing a route to responsive or dynamic gels, and that monobromo-pyridazinedione gels are able to support the proliferation of human cells. We anticipate that our results will provide a valuable and complementary addition to the existing toolkit of cross-linking agents, allowing researchers to tune and rationally design the properties of biomedical hydrogels.

Indexed as

HydrogelsSulfhydryl CompoundsCross-Linking ReagentsHumansCross-Linking ReagentsHydrogelsSulfhydryl Compounds

Identifiers

PMID37792488
PMCPMC10646975
OpenAlexW4387332229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.