Evidence map›Paper›PMID 37792440›Full record

ArticleJMIR formative research2023

Transient Elastography and Video Recovery Narrative Access to Support Recovery From Alcohol Misuse: Development of a Novel Intervention for Use in Community Alcohol Treatment Services.

Stefan Rennick-Egglestone, Mohsan Subhani, Holly Knight, Katy A Jones, Clare Hutton, Tracey Jackson, Matthew Hutton, Andrew Wragg, Joanne R Morling, Kirsty Sprange and 1 more

Open access · goldAbstract read
In one paragraph

Article in JMIR formative research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Alcohol-related liver disease and access to liver transplantation: where we stand and where we should go.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Stefan Rennick-Egglestone *School of Health Sciences, Institute of Mental Health, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-4187-011X
Mohsan Subhani *Nottingham Digestive Diseases Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0001-8739-7263
Holly Knight *Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0002-4602-3238
Katy A JonesAcademic Unit of Mental Health and Clinical Neuroscience, School of Medicine, Institute of Mental Health, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-4650-7053
Clare HuttonKLIFAD Study PPI Panel, Nottingham, United Kingdom.ORCID https://orcid.org/0009-0000-3820-1471
Tracey JacksonKLIFAD Study PPI Panel, Nottingham, United Kingdom.ORCID https://orcid.org/0009-0000-5838-7875
Matthew HuttonKLIFAD Study PPI Panel, Nottingham, United Kingdom.
Andrew WraggNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-0552-4287
Joanne R MorlingNottingham Digestive Diseases Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-0772-2893
Kirsty SprangeNottingham Clinical Trials Research Unit, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0001-6443-7242
Stephen D RyderNottingham Digestive Diseases Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0001-9649-4444
University of Nottingham · GBNottingham University Hospitals NHS Trust · GB

Funding

Medical Research Council MR/P008348/1
6 · The paper itself

Abstract

backgroundMortality from alcohol-related liver disease has risen significantly for 3 decades. Transient elastography (TE) is a noninvasive test providing a numerical marker of liver disease. Preliminary evidence suggests that TE can reduce alcohol consumption. The KLIFAD (does knowledge of liver fibrosis affect high-risk drinking behavior?) study has developed a complex intervention wherein people receiving alcohol treatment are provided with access to TE, accompanied by scripted feedback tailored to their disease state, and access to video narratives describing alcohol misuse recovery after receiving TE. Recovery narratives are included due to preliminary evidence from mental health studies which suggest that access to digital narratives describing recovery from mental health problems can help people affected by mental health problems, including through mechanisms with the potential to be transferable to an alcohol treatment setting, for example, by increasing hope for the future, enabling learning from the experience of others, or promoting help-seeking behaviors.

objectiveWe aimed to develop the KLIFAD intervention to the point that it could be delivered in a feasibility trial and to produce knowledge relevant to clinicians and researchers developing interventions making use of biomarkers of disease.

methodsIn research activity 1, standardized scripted feedback was developed by this study, and then iterated through focus groups with people who had experienced alcohol misuse and TE, and key alcohol workers with experience in delivering TE. We report critical design considerations identified through focus groups, in the form of sensitizing concepts. In research activity 2, a video production guide was coproduced to help produce impactful video-based recovery narratives, and a patient and public involvement (PPI) panel was consulted for recommendations on how best to integrate recovery narratives into an alcohol treatment setting. We report PPI recommendations and an overview of video form and content.

resultsThrough research activity 1, we learnt that patient feedback has not been standardized in prior use of TE, that receiving a numeric marker can provide an objective target that motivates and rewards recovery, and that key alcohol workers regularly tailor information to their clients. Through research activity 2, we developed a video production guide asking narrators what recovery means to them, what helped their recovery, and what they have learned about recovery. We produced 10 recovery narratives and collected PPI recommendations on maximizing impact and safety. These led to the production of unplanned videos presenting caregiver and clinician perspectives, and a choice to limit narrative availability to alcohol treatment settings, where support is available around distressing content. These choices have been evaluated through a feasibility randomized controlled trial [ISRCTN16922410].

conclusionsProviding an objective target that motivates and rewards recovery is a candidate change mechanism for complex interventions integrating biomarkers of disease. Recovery narratives can contain distressing content; intervention developers should attend to safe usage. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1136/bmjopen-2021-054954.

Indexed as

alcohol misusealcohol use disordercomplex interventionfeasibility trialKLIFAD interventionrecovery narrativerecovery story

Identifiers

PMID37792440
PMCPMC10585443
OpenAlexW4382401186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.