Evidence map›Paper›PMID 37792257›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2024

Antibacterial effects of quercetagetin are significantly enhanced upon conjugation with chitosan engineered copper oxide nanoparticles.

Adeelah Alvi, Saif Alqassim, Naveed Ahmed Khan, Bushra Khatoon, Noor Akbar, Muhammad Kawish, Shaheen Faizi, Muhammad Raza Shah, Ahmad M Alharbi, Hasan Alfahemi and 1 more

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Adeelah AlviCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055, Dubai, United Arab Emirates.
Saif AlqassimCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055, Dubai, United Arab Emirates. saif.alqassim@mbru.ac.ae.
Naveed Ahmed KhanMicrobiota Research Center, Istinye University, Istanbul, 34010, Turkey. naveed5438@gmail.com.
Bushra KhatoonInternational Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Noor AkbarResearch Institute of Medical and Health Sciences, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Muhammad KawishInternational Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Shaheen FaiziInternational Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Muhammad Raza ShahInternational Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Ahmad M AlharbiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, 21944, Taif, Saudi Arabia.
Hasan AlfahemiDepartment of Medical Microbiology, Faculty of Medicine, Al-Baha University, 65799, Al-Baha, Saudi Arabia.
Ruqaiyyah SiddiquiMicrobiota Research Center, Istinye University, Istanbul, 34010, Turkey.
International Center for Chemical and Biological Sciences · PKIstinye University · TRMohammed Bin Rashid University of Medicine and Health Sciences · AEAl Baha University · SATaif University · SAUniversity of Karachi · PKUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of antibiotic alternatives that entail distinctive chemistry and modes of action is necessary due to the threat posed by drug resistance. Nanotechnology has gained increasing attention in recent years, as a vehicle to enhance the efficacy of existing antimicrobials. In this study, Chitosan copper oxide nanoparticles (CHI-CuO) were synthesized and were further loaded with Quercetagetin (QTG) to achieve the desired (CHI-CuO-QTG). Size distribution, zeta potential and morphological analysis were accomplished. Next, the developed CHI-CuO-QTG was assessed for synergistic antibacterial properties, as well as cytotoxic attributes. Bactericidal assays revealed that CHI-CuO conjugation showed remarkable effects and enhanced QTG effects against a range of Gram + ve and Gram - ve bacteria. The MIC

Indexed as

ChitosanFlavonesMetal NanoparticlesNanoparticlesAnti-Bacterial AgentsBacteriaCopperEscherichia coliHumansMicrobial Sensitivity TestsOxidesAnti-Bacterial AgentsChitosanCoppercuprous oxideFlavonesOxidesquercetagetinChitosan copper oxide nanoparticlesCopper oxideNanoparticlesQuercetagetin

Identifiers

PMID37792257
OpenAlexW4387327070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.