Evidence map›Paper›PMID 37792076›Full record

ArticlePediatric nephrology (Berlin, Germany)2024

Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference.

Michelle C Starr, Erin Barreto, Jennifer Charlton, Molly Vega, Patrick D Brophy, O N Ray Bignall, Scott M Sutherland, Shina Menon, Prasad Devarajan, Ayse Akcan Arikan and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Research progress on biomarkers for acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Functional outcomes in pediatric patients on renal replacement therapy in a worldwide registry.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 1 country.

Michelle C StarrDepartment of Pediatrics, Division of Nephrology, Indiana University School of Medicine, Riley Hospital for Children, 1044 W. Walnut Street, Indianapolis, IN, 46202, USA.
Erin BarretoDepartment of Pharmacy, Mayo Clinic, Rochester, MN, USA.
Jennifer CharltonDepartment of Pediatrics, Division of Nephrology, University of Virginia, Charlottesville, VA, USA.
Molly VegaRenal and Apheresis Services, Texas Children's Hospital, Houston, TX, USA.
Patrick D BrophyDepartment of Pediatrics, Golisano Children's Hospital, University of Rochester, Rochester, NY, USA.
O N Ray BignallDepartment of Pediatrics, Division of Nephrology and Hypertension, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.
Scott M SutherlandDepartment of Pediatrics, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA.
Shina MenonDivision of Pediatric Nephrology, Seattle Children's Hospital and University of Washington, Seattle, WA, USA.
Prasad DevarajanDepartment of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Ayse Akcan ArikanDepartment of Pediatrics, Divisions of Critical Care and Nephrology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Rajit BasuDepartment of Pediatrics, Division of Critical Care, Northwestern University, Chicago, IL, USA.
Stuart GoldsteinDepartment of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Danielle E SorannoDepartment of Pediatrics, Division of Nephrology, Indiana University School of Medicine, Riley Hospital for Children, 1044 W. Walnut Street, Indianapolis, IN, 46202, USA. DSoranno@iu.edu.ORCID http://orcid.org/0000-0001-7019-809X
ADQI 26 workgroup
Cincinnati Children's Hospital Medical Center · USBaylor College of Medicine · USGolisano Children's Hospital · USMayo Clinic in Arizona · USNationwide Children's Hospital · USNorthwestern University · USPurdue University West Lafayette · USRiley Hospital for Children · USSeattle Children's Hospital · USStanford University · USTexas Children's Hospital · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the past decade, there have been substantial advances in our understanding of the pathobiology of pediatric acute kidney injury (AKI). In particular, animal models and studies focused on the relationship between kidney development, nephron number, and kidney health have identified a number of heterogeneous pathophysiologies underlying AKI. Despite this progress, gaps remain in our understanding of the pathobiology of pediatric AKI.

methodsDuring the 26th Acute Disease Quality Initiative (ADQI) Consensus conference, a multidisciplinary group of experts discussed the evidence and used a modified Delphi process to achieve consensus on recommendations for opportunities to advance translational research in pediatric AKI. The current state of research understanding as well as gaps and opportunities for advancement in research was discussed, and recommendations were summarized.

resultsConsensus was reached that to improve translational pediatric AKI advancements, diverse teams spanning pre-clinical to epidemiological scientists must work in concert together and that results must be shared with the community we serve with patient involvement. Public and private research support and meaningful partnerships with adult research efforts are required. Particular focus is warranted to investigate the pediatric nuances of AKI, including the effect of development as a biological variable on AKI incidence, severity, and outcomes.

conclusionsAlthough AKI is common and associated with significant morbidity, the biologic basis of the disease spectrum throughout varying nephron developmental stages remains poorly understood. An incomplete understanding of factors contributing to kidney health, the diverse pathobiologies underlying AKI in children, and the historically siloed approach to research limit advances in the field. The recommendations outlined herein identify gaps and outline a strategic approach to advance the field of pediatric AKI via multidisciplinary translational research.

Indexed as

Acute Kidney InjuryAcute DiseaseAdultAnimalsChildConsensusHumansIncidenceModels, AnimalAcute kidney injuryAnimal modelsDevelopment as a biological variableNeonatesOutcomesPediatricsTranslational research

Identifiers

PMID37792076
PMCPMC10817846
OpenAlexW4387327095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.