ArticleIntensive care medicine2023
Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation-analysis of the Extracorporeal Life Support Organization registry.
Article in Intensive care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support - a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial.Open heart · 2026Trial
- Scoping review of contemporary adult venoarterial extracorporeal membrane oxygenation (VA ECMO) selection criteria and decision-making mechanisms.The journal of extra-corporeal technology · 2026Article
- Frailty and outcomes after extracorporeal membrane oxygenation: a binational registry-based cohort study.Critical care (London, England) · 2025Article
- Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany).Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Article
- ICU capacity, ICU staffing, and postcardiotomy ECMO outcomes in China: a multilevel cross-sectional study.Critical care (London, England) · 2025Article
- Role of age in prognostication of hospital mortality in postcardiotomy patients supported with extracorporeal membrane oxygenation.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Indications for extracorporeal membrane oxygenation in older adult patients with accidental hypothermia and hemodynamic instability.BMC emergency medicine · 2025Observational
- COMPREHENSIVE CHARACTERIZATION OF CYTOKINES IN PATIENTS UNDER EXTRACORPOREAL MEMBRANE OXYGENATION: EVIDENCE FROM INTEGRATED BULK AND SINGLE-CELL RNA SEQUENCING DATA USING MULTIPLE MACHINE LEARNING APPROACHES.Shock (Augusta, Ga.) · 2025Article
- Prognostic accuracy of oxygen debt for mortality in patients undergoing venoarterial extracorporeal membrane oxygenation therapy: a retrospective cohort study.Frontiers in medicine · 2025Article
- Characterization of pathogenic bacterial distribution in extracorporeal membrane oxygenation-related nosocomial infections and the prognostic value of early inflammatory biomarkers for infection survival.Frontiers in microbiology · 2025Article
- Extracorporeal membrane oxygenation for adults with respiratory failure secondary to cardiorespiratory disease: evolving indications and clinical practice.Breathe (Sheffield, England) · 2025Review
- Management of cardiogenic shock: state-of-the-art.Intensive care medicine · 2024Review
- Article
- [Open questions with respect to extracorporeal circulatory support 2024].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Association between intensive care unit nursing grade and mortality in patients with cardiogenic shock and its cost-effectiveness.Critical care (London, England) · 2024Article
- Venoarterial extracorporeal membrane oxygenation in the treatment of postinfarction cardiogenic shock: is it the end, or do we need to select patients better?Critical care science · 2024Article
- De senectute and the art of medicine: how old is too old for ECMO in cardiogenic shock?Intensive care medicine · 2023Article
- Patient-Related Factors Associated with Adverse Outcomes Following Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVenoarterial extracorporeal membrane oxygenation (V-A ECMO) can be used to support severely ill patients with cardiogenic shock. While age is commonly used in patient selection, little is known regarding its association with outcomes in this population. We sought to evaluate the association between increasing age and outcomes following V-A ECMO.
methodsWe used individual-level patient data from 440 centers in the international Extracorporeal Life Support Organization registry. We included all adult patients receiving V-A ECMO from 2017 to 2019. The primary outcome was hospital mortality. Secondary outcomes included a composite of complications following initiation of V-A ECMO. We conducted Bayesian analyses of the relationship between increasing age and outcomes of interest.
resultsWe included 15,172 patients receiving V-A ECMO. Of these, 8172 (53.9%) died in hospital. For the analysis conducted using weakly informed priors, and as compared to the reference category of age 18-29, the age bracket of 30-39 (odds ratio [OR] 0.94, 95% credible interval [CrI] 0.79-1.10) was not associated with hospital mortality, but age brackets 40-49 (odds ratio [OR] 1.26, 95% CrI: 1.08-1.47), 50-59 (OR 1.78, 95% CrI: 1.55-2.06), 60-69 (OR 2.24, 95% CrI: 1.94-2.59), 70-79 (OR 2.90, 95% CrI: 2.49-3.39) and ≥ 80 (OR 4.02, 95% CrI: 3.13-5.20) were independently associated with increasing hospital mortality. Similar results were found in the analysis conducted with an informative prior, as well as between increasing age and post-ECMO complications.
conclusionsAmong patients receiving V-A ECMO for cardiogenic shock, increasing age is strongly associated with increasing odds of death and complications, and this association emerges as early as 40 years of age.
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