ArticlemSphere2023
Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s.
Open access · goldAbstract read
In one paragraph
Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Mechanistic insights into subclinicaliScience · 2026Review
- CAR-macrophage therapy: a novel strategy to overcome antimalarial drug resistance by targeting PfEMP1-mediated adhesion.Malaria journal · 2026Article
- Plasma From Older Children in Malawi Inhibits Plasmodium falciparum Binding in 3-Dimensional Brain Microvessels.The Journal of infectious diseases · 2024Article
- Article
- Broadly inhibitory antibodies against severe malaria virulence proteins.bioRxiv : the preprint server for biology · 2024Article
- PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity.Advances in parasitology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 5 institutions in 3 countries.
Madison A TeweyMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.ORCID 0009-0002-1865-7177
Drissa CoulibalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
Jonathan G LawtonMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Emily M StuckeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Albert E ZhouMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Andrea A BerryMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Jason A BaileyMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Andrew PikeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Antoine DaraMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
Amed OuattaraMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Kirsten E LykeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Olukemi IfeonuMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Matthew B LaurensMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.ORCID 0000-0003-3874-581X
Matthew AdamsMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Shannon Takala-HarrisonMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Amadou NiangalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
Bourema KouribaMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
Abdoulaye K KonéMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
J Alexandra RoweCentre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh , Edinburgh, United Kingdom.
Ogobara K DoumboMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
Jigar J PatelRoche NimbleGen, Inc. , Madison, Wisconsin, USA.
John C TanRoche NimbleGen, Inc. , Madison, Wisconsin, USA.
Philip L FelgnerDivision of Infectious Diseases, Department of Medicine, University of California , Irvine, California, USA.
Christopher V PloweMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.
Mahamadou A TheraMalaria Research and Training Center, University of Sciences, Techniques and Technologies , Bamako, Mali.
Mark A TravassosMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland, USA.ORCID 0000-0002-6045-3322
University of Maryland, Baltimore · USUniversité des Sciences, des Techniques et des Technologies de Bamako · MLLa Roche College · USCentre for Immunity, Infection and Evolution · GBUniversity of California, Irvine · US
Funding
EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9MFELLOWSHIP TRAINING PROGRAM IN VACCINOLOGYT32AI007524 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1997 to 2026
$6.4MVariant surface antigens in cerebral malaria pathogenesisR01HL130750 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI FISHER, STEVEN A., PLOWE, CHRISTOPHER V. · 2015 to 2018
$2.1MMalaria variant surface antigen expression and vulnerability to disease in Malian children with Hemoglobin C traitR01HL146377 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TRAVASSOS, MARK A · 2019 to 2023
$1.9MProtein microarray antibody responses to P. falciparum in a human challenge modelK23AI125720 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BERRY, ANDREA · 2017 to 2021
$915kHost vulnerability and parasite genetics in the development of cerebral malariaR01AI099628 · NIAID · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI THERA, MAHAMADOU ALI · 2014 to 2018
$625kUltra-dense peptide array analysis of naturally acquired and vaccine-induced P. falciparum immunityR21AI119733 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BERRY, ANDREA · 2016 to 2017
$361kDeciphering the roles of RIFIN and STEVOR parasite antigens in severe malaria pathogenesis via transcriptomics and immune profilingF31AI178915 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAWTON, JONATHAN · 2023 to 2024
$70kNHLBI NIH HHS R01 HL130750NHLBI NIH HHS R01 HL146377NIAID NIH HHS F31 AI178915NIAID NIH HHS K23 AI125720NIAID NIH HHS R01 AI099628NIAID NIH HHS R21 AI119733NIAID NIH HHS T32 AI007524NIGMS NIH HHS R25 GM055036
Abstract
Antibody responses to variant surface antigens (VSAs) produced by the malaria parasite
Indexed as
MalariaMalaria, FalciparumAdultChildChild, PreschoolEndothelial Protein C ReceptorEpitopesHumansPeptidesProtozoan ProteinsEndothelial Protein C ReceptorEpitopesPeptidesProtozoan ProteinsCIDRα1endothelial protein C receptorMalariamicroarraypeptidePfEMP1Plasmodium falciparumsevere malariavariant surface antigen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.