Evidence map›Paper›PMID 37791757›Full record

ArticleApplied and environmental microbiology2023

Three alginate lyases provide a new gut

Mette E Rønne, Tobias Tandrup, Mikkel Madsen, Cameron J Hunt, Pernille N Myers, Janne M Moll, Jesper Holck, Susanne Brix, Mikael L Strube, Finn L Aachmann and 2 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Hindguts ofmSystems · 2025
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mette E RønneDepartment of Biotechnology and Biomedicine, Enzyme and Protein Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-7892-4655
Tobias TandrupDepartment of Biotechnology and Biomedicine, Enzyme and Protein Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-3448-7019
Mikkel MadsenDepartment of Biotechnology and Biomedicine, Enzyme and Protein Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-3748-9132
Cameron J HuntDepartment of Biotechnology and Biomedicine, Enzyme Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-8495-0542
Pernille N MyersDepartment of Biotechnology and Biomedicine, Disease Systems Immunology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-1824-3305
Janne M MollDepartment of Biotechnology and Biomedicine, Disease Systems Immunology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-3514-4528
Jesper HolckDepartment of Biotechnology and Biomedicine, Enzyme Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-8072-1101
Susanne BrixDepartment of Biotechnology and Biomedicine, Disease Systems Immunology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0001-8951-6705
Mikael L StrubeDepartment of Biotechnology and Biomedicine, Bacterial Ecophysiology and Biotechnology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0003-0905-5705
Finn L AachmannDepartment of Biotechnology and Food Science, Norwegian Biopolymer Laboratory (NOBIPOL), NTNU Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-1613-4663
Casper WilkensDepartment of Biotechnology and Biomedicine, Enzyme Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0001-7692-067X
Birte SvenssonDepartment of Biotechnology and Biomedicine, Enzyme and Protein Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-2993-8196

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans consume alginate in the form of seaweed, food hydrocolloids, and encapsulations, making the digestion of this mannuronic acid (M) and guluronic acid (G) polymer of key interest for human health. To increase knowledge on alginate degradation in the gut, a gene catalog from human feces was mined for potential alginate lyases (ALs). The predicted ALs were present in nine species of the Bacteroidetes phylum, of which two required supplementation of an

Indexed as

AlginatesBacteriaBacteroidesHumansOligosaccharidesPolysaccharide-LyasesSubstrate SpecificityAlginatesOligosaccharidespoly(beta-D-mannuronate) lyasePolysaccharide-Lyasesalginate lyaseBacteroides ovatusBacteroidetescrystal structuregenome miningmetagenomic gene catalogmode of actionpolysaccharide utilization lociproteome analysissynergy

Identifiers

PMID37791757
PMCPMC10617595

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.