Evidence map›Paper›PMID 37790586›Full record

ReviewFrontiers in neuroscience2023

Decoding the role of gut microbiota in Alzheimer's pathogenesis and envisioning future therapeutic avenues.

Junyi Liang, Bin Liu, Xiaohong Dong, Yueyang Wang, Wenhui Cai, Ning Zhang, Hong Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junyi LiangHeilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Bin LiuHeilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Xiaohong DongHeilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Yueyang WangHeilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Wenhui CaiHeilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Ning ZhangHeilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Hong ZhangHeilongjiang Jiamusi Central Hospital, Jiamusi, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) emerges as a perturbing neurodegenerative malady, with a profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry of human health and affliction, the enteric microbial consortium, ensconced within the milieu of the human gastrointestinal tract, assumes a role of cardinal significance. Recent epochs have borne witness to investigations that posit marked divergences in the composition of the gut microbiota between individuals grappling with AD and those favored by robust health. The composite vicissitudes in the configuration of the enteric microbial assembly are posited to choreograph a participatory role in the inception and progression of AD, facilitated by the intricate conduit acknowledged as the gut-brain axis. Notwithstanding, the precise nature of this interlaced relationship remains enshrouded within the recesses of obscurity, poised for an exhaustive revelation. This review embarks upon the endeavor to focalize meticulously upon the mechanistic sway exerted by the enteric microbiota upon AD, plunging profoundly into the execution of interventions that govern the milieu of enteric microorganisms. In doing so, it bestows relevance upon the therapeutic stratagems that form the bedrock of AD's management, all whilst casting a prospective gaze into the horizon of medical advancements.

Indexed as

Alzheimer’s diseasegut-brain axis mechanismgut microbiotainflammationmemorytraditional Chinese medicinetreatment research advancements

Identifiers

PMID37790586
PMCPMC10544353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.