Evidence map›Paper›PMID 37790524›Full record

ArticleResearch square2023

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia.

Jeffery Klco, Melvin Thomas, Wenqing Qi, Michael Walsh, Jing Ma, Tamara Westover, Sherif Abdelhamed, Lauren Ezzell, Chandra Rolle, Emily Xiong and 5 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Jeffery KlcoSt. Jude Children's Research Hospital.ORCID 0000-0003-2961-6960
Melvin ThomasSt. Jude Children's Research Hospital.
Wenqing QiSt. Jude Children's Research Hospital.
Michael WalshSt. Jude Childrens Hospital.
Jing MaSt. Jude Children's Research Hospital.
Tamara WestoverSt. Jude Children's Research Hospital.
Sherif AbdelhamedSeagen.
Lauren EzzellSt. Jude Children's Research Hospital.
Chandra RolleSt. Jude Children's Research Hospital.
Emily XiongSt. Jude Children's Research Hospital.
Wojciech RosikiewiczSt. Jude Children's Research Hospital.
Beisi XuSt Jude Children's Research Hospital.ORCID 0000-0003-0099-858X
Shondra Pruett-MillerSt. Jude Children's Research Hospital.ORCID 0000-0002-3793-585X
Allister LoughranSt. Jude Children's Research Hospital.
Laura JankeSt. Jude Children's Research Hospital.
St. Jude Children's Research Hospital · USSeagen (Canada) · CA

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Cellular and functional impact of SAMD9L mutations on hematopoiesis and myelodysplasiaR01HL144653 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KLCO, JEFFERY M · 2019 to 2023
$2.2M
The Molecular and Biochemical Function of SAMD9 and SAMD9L in Pediatric MDSF32HL152484 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI THOMAS, MELVIN EDWARD · 2020 to 2022
$155k
NCI NIH HHS P30 CA021765NHLBI NIH HHS F32 HL152484NHLBI NIH HHS R01 HL144653
6 · The paper itself

Abstract

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in

Indexed as

AMLMGAMYC regulationncPRC1.6RUNX1:RUNX1T1

Identifiers

PMID37790524
PMCPMC10543392
OpenAlexW4386957587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.