Evidence map›Paper›PMID 37790492›Full record

ArticlebioRxiv : the preprint server for biology2023

Validation of Dual Energy X-ray Absorptiometry for longitudinal quantification of tumor burden in a murine model of pancreatic ductal adenocarcinoma.

Zachary R Sechrist, Grace Lee, Edward M Schwarz, Calvin L Cole

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zachary R SechristDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Grace LeeDepartment of Biology, University of Rochester, Rochester, New York, United States.
Edward M SchwarzDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Calvin L ColeDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States.
University of Rochester Medical Center · USUniversity of Rochester · US

Funding

Training and Research on Mechanisms of Pancreatic Cancer Associated Muscle Wasting and Related TherapiesK01CA240533 · NCI · UNIVERSITY OF ROCHESTER · PI COLE, CALVIN LLOYD · 2021 to 2025
$714k
NCI NIH HHS K01 CA240533
6 · The paper itself

Abstract

Noninvasive imaging is central to preclinical, in vivo models of pancreatic ductal adenocarcinoma (PDAC). While bioluminescent imaging (BLI) is a gold standard, its signal is dependent on the metabolic activity of tumor cells. In contrast, dual energy X-ray absorptiometry (DEXA) is a direct measure of body composition. Thus, we aimed to assess its potential for longitudinal quantification of tumor burden versus BLI. We utilized the KCKO murine model of PDAC and subjected tumor-bearing (n = 20) and non-tumor control (NTC) (n = 10) animals to weekly BLI and DEXA measurements for up to 10 weeks. While BLI detected tumors at 1-week, it failed to detect tumor growth, displayed a decreasing trend overtime (slope = -9.0×10

Identifiers

PMID37790492
PMCPMC10542135
OpenAlexW4386859400

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.