Evidence map›Paper›PMID 37790466›Full record

ArticleResearch square2023

Learning to Express Reward Prediction Error-like Dopaminergic Activity Requires Plastic Representations of Time.

Ian Cone, Claudia Clopath, Harel Z Shouval

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ian ConeDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Claudia ClopathDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Harel Z ShouvalDepartment of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX.ORCID 0000-0003-2799-1337
Imperial College London · GBRice University · US

Funding

Learning spatio-temporal statistics from the environment in recurrent networksR01EB022891 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BRUNEL, NICOLAS, SHOUVAL, HAREL ZEEV · 2016 to 2018
$1.2M
NIBIB NIH HHS R01 EB022891Wellcome Trust
6 · The paper itself

Abstract

The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference (TD) reinforcement learning. The TD framework predicts that some neuronal elements should represent the reward prediction error (RPE), which means they signal the difference between the expected future rewards and the actual rewards. The prominence of the TD theory arises from the observation that firing properties of dopaminergic neurons in the ventral tegmental area appear similar to those of RPE model-neurons in TD learning. Previous implementations of TD learning assume a fixed temporal basis for each stimulus that might eventually predict a reward. Here we show that such a fixed temporal basis is implausible and that certain predictions of TD learning are inconsistent with experiments. We propose instead an alternative theoretical framework, coined FLEX (

Identifiers

PMID37790466
PMCPMC10543312
OpenAlexW4386819935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.