Evidence map›Paper›PMID 37790437›Full record

ArticlebioRxiv : the preprint server for biology2023

Activity-dependent development of the body's touch receptors.

Celine Santiago, Nikhil Sharma, Nusrat Africawala, Julianna Siegrist, Annie Handler, Aniqa Tasnim, Rabia Anjum, Josef Turecek, Brendan P Lehnert, Sophia Renauld and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Celine SantiagoDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Nikhil SharmaDepartment of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
Nusrat AfricawalaDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Julianna SiegristDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Annie HandlerDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Aniqa TasnimDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Rabia AnjumDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA, 02453, USA.
Josef TurecekDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Brendan P LehnertDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Sophia RenauldDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Michael Nolan-TamarizDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Michael IskolsDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Alexandra R MageeDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Suzanne ParadisDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA, 02453, USA.
David D GintyDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, 02115, USA.
Howard Hughes Medical Institute · USBrandeis University · USColumbia University · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS097344 · NINDS · HARVARD MEDICAL SCHOOL · PI GINTY, DAVID D · 2016 to 2023
$6.8M
Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate PainR01AT011447 · NCCIH · HARVARD MEDICAL SCHOOL · PI DRUGOWITSCH, JAN, GINTY, DAVID D · 2020 to 2024
$5.3M
The cellular and molecular mechanisms underlying nociception and painDP2NS127278 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHARMA, NIKHIL · 2021 to 2024
$2.4M
Peripheral Activity-Dependent and Molecular Mechanisms that Control Somatosensory System DevelopmentK99NS124993 · NINDS · HARVARD MEDICAL SCHOOL · PI SANTIAGO, CELINE · 2022 to 2023
$200k
NCCIH NIH HHS R01 AT011447NICHD NIH HHS P50 HD105351NINDS NIH HHS DP2 NS127278NINDS NIH HHS K99 NS124993NINDS NIH HHS R35 NS097344
6 · The paper itself

Abstract

We report a role for activity in the development of the primary sensory neurons that detect touch. Genetic deletion of Piezo2, the principal mechanosensitive ion channel in somatosensory neurons, caused profound changes in the formation of mechanosensory end organ structures and altered somatosensory neuron central targeting. Single cell RNA sequencing of

Identifiers

PMID37790437
PMCPMC10542488
OpenAlexW4386994581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.